【摘要】 提出一种利用平行排列的双排压电喷嘴喷射海藻酸钠和氯化钙两种组分的溶液进行大尺寸水凝胶支架制造的方法，研究了不同溶液组分与打印工艺参数对流变特性与喷射性能的关系。研究表明：适合双组分喷墨打印的最佳溶液质量浓度为40 g/L，最佳打印工艺参数组合为电压幅值80～100 V、打印频率0.2～5 k Hz。在此参数下完成了尺寸60 mm×30 mm×1 mm海藻酸钙凝胶支架的打印。该打印方法工艺简单、效率高、材料利用率高，有望应用于结构复杂的组织工程支架的一体化制造中。更多还原

【Abstract】 A method of producing a large size of hydrogel scaffold by spraying two components of sodium alginate and calcium chloride solution with two rows of parallel piezoelectric nozzles was proposed,and the relationship between rheological properties and spray properties of different solution components and printing process parameters was studied. The result showed that the optimum concentration of solution for inkjet printing is determined to be 40 g/L,and the range of voltage amplitude and printing frequency suitable for bicomponent inkjet printing hydrogel scaffolds are determined to be 80 ～120 V and 0.2 ～5 kHz respectively. Under this printing parameter,a calcium alginate hydrogel scaffold with a size of 60 mm×30 mm×1 mm was printed. The bicomponent multiple nozzles inkjet 3D printing method has the advantages of simple printing process,high efficiency and high material utilization,which is expected to be applied to the integrated manufacturing of tissue engineering scaffolds with complex structures.更多还原