【摘要】 目的 评估磁化准备快速采集梯度回波(MPRAGE)磁共振成像序列检查下肢深静脉血栓(DVT)的临床价值。方法 对43例经超声确诊或疑似有DVT的患者进行MPRAGE和对比增强磁共振静脉血管造影(CE-MRV)检查，并评估采集得到图像的图像质量及诊断信心分数(四分法：1-最差，4-最好)。结果 MPRAGE和CE-MRV均获得较好的图像质量和诊断信心分数，MPRAGE的图像质量评分结果 比CE-MRV稍低(平均值：3.62±0.64 vs 3.72±0.51,P<0.001)，两者的诊断信心分数无统计差异(平均值：3.67±0.62vs3.68±0.54, P=0.572)。结论 MPRAGE可准确地诊断DVT患者，其检查结果 与CE-MRV一致性高，可以作为安全、方便的替代方法 。更多还原

【Abstract】 Objective To evaluate a magnetic resonance(MR) sequence, magnetization prepared rapid acquisition gradient echo(MPRAGE), for the diagnosis of deep vein thrombosis(DVT). Methods Forty-three DVT patients confirmed by ultrasound were recruited and then conductedby MPRAGE and contrastenhanced MR venography(CE-MRV). The image quality and diagnosticconfidence of both MPRAGE and CE-MRV were assessed on a 4-point scale(1: poor; 4: excellent). Using the consensus CE-CMRV as a reference, the sensitivity, specificity, positive and negative predictivevalues, and accuracy of MPRAGE in the diagnosis of DVT patients were calculated. Wilcoxonsigned rank test was used for the comparison of the image quality and diagnostic confidence scores between MPRAGE and CE-MRV. Interobserver agreement and agreement between MPRAGE and CE-CMRV were tested using Cohen’s κ test. Results Good image quality and diagnostic confidence scores were obtained by both MPRAGE and CE-MRV. Although the image quality of MPRAGE was slightly lower than that of CE-MRV(3.62±0.64 vs 3.72±0.51, P<0.001), their diagnostic confidence scores were comparable(3.67±0.62 vs 3.68±0.54, P=0.572). Conclusion MPRAGE has high accuracy for the diagnosis of DVT. It is a safe and complementary technique for diagnosing the suspected DVT patients.更多还原