【摘要】 目的 本研究基于体素镜像同伦连接（voxel mirror homunculus connection, VMHC）方法，针对2型糖尿病（type2 diabetes mellitus, T2DM）患者进行大脑半球同伦功能连接的研究。材料与方法 本试验为横断面研究，根据纳排标准，选取2020年8月至2021年12月来自江西省人民医院的T2DM患者22例纳入T2DM组和从社会招募的正常对照者22例（性别、年龄及文化程度与T2DM组患者相匹配）纳入正常对照组，两组患者均进行3.0 T磁共振扫描，应用DPABI＿V4.0软件及SPM8对磁共振数据进行预处理，使用VMHC方法分析两组受试者的全脑镜像同伦连接，采用两样本t检验比较组间差异，并分析显著差异脑区平均标准化VMHC值与空腹血糖值相关性。结果 与正常对照组相比，T2DM组双侧小脑小叶Ⅸ区VMHC值均升高（GRF校正，体素水平P<0.001,簇水平P<0.05），但差异脑区的平均标准化VMHC值与空腹血糖值无显著相关性（P>0.05）。结论 T2DM患者双侧小脑半球同伦功能连接异常，可能为T2DM患者脑损伤的发病机制提供参考。更多还原

【Abstract】 Objective: This study aimed to investigate the hemispheric homunculus functional connectivity in type 2 diabetes mellitus(T2DM) patients using the voxel mirror homunculus connection(VMHC) method. Materials and Methods: This was a cross-sectional study, according to the inclusion criteria, 22 patients with T2DM from the Jiangxi Provincial People’s Hospital from August 2020 to December 2021 were selected to the T2DM group and 22 healthy controls recruited from the community(sex, age and education level matched with patients in the T2DM group) were selected to the normal control group. Both groups underwent 3.0 T MRI scans, and then applied DPABI＿V4.0 software and SPM8 to preprocess the MRI data, the differences in whole brain mirror homologous connections between the two groups of subjects were analyzed by the VMHC method, the differences in VMHC values between the two groups were analyzed by a paired two-sample t-test and the correlation between mean standardized VMHC values and fasting glucose values in significantly different brain regions was analyzed. Results: Compared to healthy controls, VMHC values were higher in the diabetic group(GRF corrected, P<0.001 for voxel level, P<0.05 for cluster level) in both cerebellar lobule Ⅸ regions, and the mean standardized VMHC values in the differential brain regions did not correlate significantly with fasting glucose values(P>0.05). Conclusions: The abnormalities in the functional connectivity of the bilateral cerebellar hemispheres with homunculus in T2DM patients may provide a reference for the pathogenesis of brain injury in T2DM patients.更多还原