【摘要】 在细菌群落中，正常细胞可以转化为持留细胞，从而增加反复感染的风险.在定量生物学中，将细胞个数的相对涨落称为噪声.为了既维持细胞平衡态的稳定性又避免感染反复，该文基于稳定性因子研究了在细菌群落中细胞的噪声特性.研究结果表明：当稳定性因子达到某阈值时，这2种细胞的噪声相互交换并迅速超越强关联区，使得持留细胞的噪声远大于正常细胞的噪声，导致持留细胞几乎完全被正常细胞消除，感染被治愈；稳定性因子的值越大，这2种细胞的平衡态越稳定，每个细胞相对越独立，感染越容易被治愈.该结果可为临床上治疗反复感染提供理论解决方案.更多还原

【Abstract】 In bacterial communities, normal cells(NCs) can transform into persistent cells(PCs),thereby increasing the risk of recurringinfections.In quantitative biology, the relative fluctuation in cell numbers is called noise.In order to maintain the stability of cell equilibrium and avoid recurrent infections, the noise characteristics in bacterial communities are studied based on the stability factor.When the stability factor reaches a certain threshold, the noises of the two phenotypes exchange with each other and quickly exceed the strong correlation region, resulting in the noise of PCs being much larger than that of NCs, so that PCs are almost completely eliminatedby NCs, and the infection is cured.The larger the value of the stability factor is, the more stable the equilibrium state of the two phenotypes is, the more independent each phenotype is, and the easier the infection is to be cured.The results may provide a theoretical solution for the clinical treatment of recurrent infections.更多还原