【摘要】 目的：观察电针胃俞募配穴对功能性消化不良（FD）大鼠脑功能局部一致性（ReHo）的影响，探索针刺治疗FD的中枢机制。方法：将18只SD乳鼠随机分为对照组、模型组、针刺组，每组6只。模型组、针刺组统一采用0.1%碘乙酰胺混合蔗糖溶液灌胃法与夹尾打斗法，配合不规则喂食制备FD模型。造模后，仅对针刺组中脘和胃俞进行电针刺激，每次20 min，每日1次，共10 d。采用小动物静息态功能磁共振成像技术观察大鼠脑区BOLD信号ReHo值变化，并记录其胃排空率与高架十字迷宫开臂时间比（OT%）。结果：与对照组比较，模型组胃排空率与OT%显著降低（P<0.05），其躯体感觉皮层（SC）、视觉皮层（VC）、脑岛皮质和扣带回皮质ReHo显著降低，丘脑（Tha）、基底外侧杏仁核（BLA）的ReHo显著升高（P<0.05,cluster>20）；与模型组比较，针刺组胃排空率和OT%显著增高（P<0.05），出现了SC、VC以及听觉皮质的ReHo显著升高，Tha、BLA的ReHo显著降低（P<0.05,cluster>20）。结论：电针干预后SC、VC、Tha、BLA脑区的ReHo值均发生了显著改变，这可能是电针胃俞募配穴治疗FD的中枢机制之一。更多还原

【Abstract】 Objective: To observe the effects of electro-acupuncture on stomach Shu-Mu points on the local consistency(Re Ho) of brain function in rats with functional dyspepsia(FD), and to explore the central mechanism of acupuncture treatment of FD. Methods: Eighteen SD rats were randomly divided into control group, model group and acupuncture group, 6 rats in each group. The model group and the acupuncture group were uniformly fed with 0.1% iodoacetamide mixed with sucrose solution by gavage and tail-pinch fighting, and were fed irregularly to prepare the FD model. After modeling, only the acupuncture group were stimulated with electro-acupuncture(EA) at Zhongwan and Weishu, 20 min each time, once a day, for a total of 10 days. Small animal resting-state functional magnetic resonance imaging was used to observe the changes of ReHo value of BOLD signal in rat brain area, and the ratio of gastric emptying rate to open arm time(OT%) of elevated plus maze was recorded. Results: Compared with the control group, the gastric emptying rate and OT% of the model group were significantly decreased(P<0.05), the ReHo of the somatosensory cortex(SC), visual cortex(VC), insula cortex and cingulate cortex were significantly decreased(P<0.05), the Re Ho of the thalamus(Tha) and basolateral amygdala(BLA) were significantly increased(P<0.05, cluster>20). Compared with the model group, the gastric emptying rate and OT% in the acupuncture group were significantly increased(P<0.05), the ReHo of SC,VC and auditory cortex were increased, and the ReHo of Tha and BLA were decreased(P<0.05, cluster>20). Conclusion: The ReHo values of SC, VC, Tha, BLA brain regions were significantly changed after electro-acupuncture intervention, which may be one of the central mechanisms of EA at stomach Shu-Mu points in the treatment of FD.更多还原