【摘要】 自噬是广泛存在于真核细胞中的基本生命现象,是细胞适应环境变化、防御病原微生物侵袭、维持内环境稳定的重要机制。炎症性肠病(IBD)是一类高发的、病因尚未明确的慢性自身免疫性疾病,在全世界范围内发病率呈上升趋势。研究发现自噬与IBD的发生和发展有着密不可分的关系,文章就自噬对IBD发病机制的影响进行综述,并总结对IBD有效的中药活性成分及其对自噬的影响,以期为IBD治疗提供新思路。更多还原

【Abstract】 Autophagy is a basic life phenomenon widely existing in eukaryotic cells, and an important mechanism for cells to adapt to environmental changes, defend against pathogenic microorganisms, and maintain internal environment stability.Inflammatory bowel disease(IBD) is a type of chronic autoimmune disease with a high incidence and an unclear etiology, and its incidence is increasing worldwide. Studies have found that autophagy is closely related to the occurrence and development of IBD. This article reviews the effects of autophagy on the pathogenesis of IBD, and summarizes the active ingredients of traditional Chinese medicines that are effective for IBD and their effects on autophagy, with a view to treating IBD Provide new ideas.更多还原