【摘要】 激光间质热疗(laser interstitial thermal therapy, LITT)是一种临床治疗深部脑肿瘤的手段，而采用有限元仿真技术可以较为精准地预测肿瘤消融区的温度变化与组织损伤情况。温度场仿真的关键技术包括光传输理论的求解、生物传热方程的计算和靶区组织的热损伤评估。在消融过程中，肿瘤组织动态光热参数、激光光纤波长、光纤直径及其排布情况对消融效果均有显著影响，而联合纳米粒子技术的LITT仿真模拟将是新的研究方向。本文对脑肿瘤激光间质热疗温度场仿真技术的研究现状进行综述，以期为提高临床疗效提供数据分析。更多还原

【Abstract】 Laser interstitial thermal therapy(LITT) is a clinical method for the treatment of deep brain tumors, and finite element simulation technology can more accurately predict the temperature change and tissue damage in the tumor ablation area. The key technologies of temperature field simulation include the solution of light transport theory, calculation of biological heat transfer equation and thermal damage assessment of target tissue. During the ablation process, the dynamic photothermal parameters of tumor tissue, the wavelength of the laser fiber, the diameter of the fiber and its arrangement have a significant impact on the ablation effect, and the LITT simulation combined with nanoparticle technology may be a new research direction. In this paper, the research status of temperature field simulation technology of laser interstitial thermal therapy for brain tumor is reviewed, in order to provide data analysis for improving clinical efficacy.更多还原