【摘要】 目的 探讨Ki-67、表皮生长因子受体（EGFR）在室管膜瘤中的表达及与患者预后的关系。方法 取84例室管膜瘤患者的肿瘤组织及相应癌旁组织（距肿瘤组织﹥3 cm），免疫组化法检测Ki-67、EGFR的表达情况。随访2年，记录患者的预后情况，室管膜瘤患者预后的影响因素采用多元Logistic回归模型分析。结果 室管膜瘤患者肿瘤组织中Ki-67、EGFR阳性表达率均明显高于癌旁组织，差异均有统计学意义（P﹤0.01）。组织学分级为Ⅲ～Ⅳ级的室管膜瘤患者肿瘤组织中Ki-67、EGFR阳性表达率均明显高于Ⅰ～Ⅱ级患者，差异均有统计学意义（P﹤0.01）。随访2年，84例室管膜瘤患者预后好转68例，预后不良16例，预后好转与预后不良室管膜瘤患者肿瘤部位、组织学分级、Ki-67表达情况、EGFR表达情况比较，差异均有统计学意义（P﹤0.05）。多元Logistic回归分析结果显示，肿瘤部位为幕下、组织学分级为Ⅲ～Ⅳ级、Ki-67阳性表达、EGFR阳性表达均为室管膜瘤患者预后不良的独立危险因素（P﹤0.05）。结论 Ki-67、EGFR在室管膜瘤中的阳性表达率较高，肿瘤部位为幕下、组织学分级为Ⅲ～Ⅳ级、Ki-67阳性表达、EGFR阳性表达均为室管膜瘤患者预后不良的独立危险因素。更多还原

【Abstract】 Objective To investigate the expression of Ki-67 and epidermal growth factor receptor(EGFR) in ependymoma and their relationship with the prognosis of patients. Method The tumor tissues and corresponding adjacent tissues(>3 cm from the tumor tissue) of 84 patients with ependymoma were collected, and the expressions of Ki-67 and EGFR were detected by immunohistochemistry. The patients were followed up for 2 years, and the prognosis of the patients was recorded. The influencing factors of the prognosis of patients with ependymoma were analyzed by multivariate Logistic regression model. Result The positive expression rates of Ki-67 and EGFR in tumor tissues of patients with ependymoma were significantly higher than those in adjacent tissues, and the differences were statistically significant(P<0.01).The positive expression rates of Ki-67 and EGFR in the tumor tissue of ependymoma patients with histological grades IIIIV were significantly higher than those of patients with grades I-II, and the differences were statistically significant(P<0.01). After 2 years of follow-up, 68 of 84 ependymoma patients had improved prognosis and 16 had poor prognosis.There were differences in tumor location, histological grade, Ki-67 expression and EGFR expression between improved and poor prognosis ependymoma patients, and the differences were statistically significant(P<0.05). The results of multivariate Logistic regression analysis showed that infratentorial tumor location, histological grade III-IV, positive expression of Ki-67, and positive expression of EGFR were independent risk factors for poor prognosis in patients with ependymoma(P<0.05). Conclusion The positive expression rates of Ki-67 and EGFR in ependymoma were high. The tumor location was under the tentorium, the histological grade was III-IV, the positive expression of Ki-67 and EGFR were independent risk factors for poor prognosis in ependymoma patients.更多还原