【摘要】 目的 探讨液基薄层细胞学检查（TCT）对不同年龄女性宫颈病变的诊断价值。方法 选取6500例体检者，均接受TCT检查，评估TCT检查诊断不同年龄段宫颈病变的检出及分布情况，分析TCT检查对宫颈病变的诊断效能。结果 随着年龄的增长，TCT检查对宫颈病变的阳性检出率不断升高，51～60岁、61～80岁女性的TCT阳性检出率分别为9.86%(71/720)、10.00%(60/600)，均高于18～20岁女性的6.85%(111/1620)，差异均有统计学意义（P﹤0.05）。病理活检结果显示，6500例体检者中，正常或炎症5960例，宫颈上皮内瘤变（CIN）Ⅰ患者141例，CINⅡ患者135例，CINⅢ患者169例，鳞状细胞癌患者95例。TCT检查诊断宫颈病变与病理活检结果的诊断符合率为95.25%(6191/6500)。TCT检查诊断宫颈病变的灵敏度为80.56%，特异度为98.57%，假阳性率为1.43%，假阴性率为19.44%，阳性预测值为83.65%，阴性预测值为1.76%。结论 各年龄层女性接受TCT检查对宫颈病变的检出率均较高，可广泛应用于临床，尤其适合年龄20～30岁不适用人乳头瘤病毒（HPV）检测的人群。更多还原

【Abstract】 Objective To investigate the diagnostic value of thin-prep cytology test(TCT) for cervical lesions in women of different ages. Method A total of 6500 physical examinations were selected and all received TCT examination. The detection and distribution of cervical lesions in different age groups were evaluated by TCT examination, and the diagnostic efficiency of TCT examination in cervical lesions was analyzed. Result With the increase of age, the positive detection rate of TCT examination for cervical lesions continued to increase. The positive detection rates of TCT in women aged 51-60 and 61-80 were 9.86%(71/720) and 10.00%(60/600), respectively, which were higher than 6.85%(111/1620) of women aged 18-20 years, and the differences were statistically significant(P<0.05). The pathological biopsy results showed that among the 6500 physical examinations, 5960 were normal or inflammatory, 141 were cervical intraepithelial neoplasia(CIN) I, 135 were CIN II, 169 were CIN III, and 95 were squamous cell carcinoma. The diagnostic coincidence rate of TCT in diagnosing cervical lesions and pathological biopsy results was 95.25%(6191/6500). The sensitivity of TCT in diagnosing cervical lesions was 80.56%, the specificity was 98.57%, the false positive rate was 1.43%,the false negative rate was 19.44%, the positive predictive value was 83.65%, and the negative predictive value was1.76%. Conclusion The results of human papilloma virus(TCT) have nothing to do with age. The detection rate of cervical lesions by TCT in women of all ages is relatively high, and it can be widely used in clinical practice, especially for people aged 20-30 who are not suitable for human papilloma virus(HPV) testing.更多还原