【摘要】 目的比较不同证型肺结核患者抗结核药物血药浓度的差异,为临床调整用药提供指导。方法选取初治肺结核患者,根据中医证候分为肺阴亏损、阴虚火旺、气阴耗伤、阴阳两虚四型。各型患者分别服用抗结核药,用药7 d后,用高效液相色谱法(HPLC)测定患者抗结核药物异烟肼和利福平的血药浓度,不同证型间进行对比。结果异烟肼血药浓度在不同证型中比较,差异统计学意义(P <0.05),其中气阴耗伤证患者的异烟肼血药浓度低于其他3型(P <0.05);在4证型中利福平血药浓度比较,差异无统计学意义(P>0.05)。结论不同证型肺结核患者血清中异烟肼血药浓度存在差异,需要根据病情和中医证型进行血药浓度的监测进而调整剂量。更多还原

【Abstract】 Objective To compare the different syndrome types of pulmonary tuberculosis effect on serum concentration of anti tuberculosis drugs and to provide clinical basis.. Methods Patients with pulmonary tuberculosis were selected and divided Lung yin deficiency type, Hyperactivity of fire syndrome,Qi and yin deficiency type and Yin and yang deficiency type according to TCM syndrome, who received anti tuberculosis drugs of isoniazid and rifampicin respectively, the serum concentration of anti tuberculosis drugs was detected by applying HPLC and the concentration of four types was compared. Results The difference of isoniazid serum concentration of four types was of statistical significance(P < 0.05), the difference of rifampicin of four types was of no statistical significance. The isoniazid serum concentration of Qi and yin deficiency type was lower than that of other three types(P < 0.05).Conclusion There was difference in isoniazid serum concentration of different syndrome types of patients with pulmonary tuberculosis.the dose should be adjusted based on the disease condition and syndrome of TCM.更多还原