【摘要】 目的分析1990～2019年中国结直肠癌(colorectal cancer,CRC)疾病负担的变化趋势。方法利用2019年全球疾病负担数据,采用发病率、死亡率、伤残调整寿命年(disability-adjusted life year,DALY)、过早死亡损失寿命年(years of life lost,YLL)、伤残损失寿命年(years lived with disability,YLD)及其标化率和平均年度百分比变化率(annual average percentage change,AAPC)对1990～2019年间中国CRC疾病负担情况进行分析。结果与1990年相比,2019年中国CRC发病例数、标化发病率、死亡例数和标化死亡率分别上升了474.03%、144.01%、230.14%和36.15%。2010年以后中国CRC标化死亡率和标化发病率逐渐超过全球水平。1990～2019年,中国CRC的总体标化发病率(AAPC=3.6%,P<0.05)、标化死亡率(AAPC=1.4%,P<0.05)和标化DALY率(AAPC=1.2%,P<0.05)总体均呈上升趋势。男性发病率、死亡率和DALY率均高于女性,且随着年龄的增长而逐渐升高。与1990年相比,2019年CRC的DALY、YLL和YLD分别上升了134.3%、127.69%和445.00%,标化DALY、YLL和YLD分别上升了30.53%、27.03%和187.29%。结论从1990年到2019年,中国CRC标化发病率和标化死亡率呈现不断增长趋势,尤其是在男性和老年人群中,应采取针对性的措施进行预防和管理。更多还原

【Abstract】 Objective To analyze the trend of disease burden of colorectal cancer(CRC) in China from 1990 to2019. Methods Data was obtained from Global Burden of Disease Study 2019(GBD 2019). Incidence, mortality,disability-adjusted life year(DALY), years of life lost(YLL), years lived with disability(YLD), and their corresponding standardized rate and annual average percentage change(AAPC) were used to describe the changes of disease burden of colorectal cancer in Chinese population between 1990 and 2019. Results Compared with 1990, the number of new cases,standardized incidence, the number of deaths and standardized mortality of CRC in China in 2019 increased by 474.03%,144.01%, 230.14%, and 36.15%, respectively. The standardized mortality and standardized incidence of CRC in China had reached and gradually exceeded the global level since 2010. From 1990 to 2019, the overall standard incidence(AAPC=3.6%, P<0.05), standard mortality rate(AAPC=1.4%, P<0.05), and the standard DALY rate(AAPC=1.2%, P<0.05)of CRC in China showed an increasing trend. The incidence, mortality and DALY rates of males were higher than those of females, and gradually increased with age. Compared with 1990, the DALY, YLL, and YLD of CRC in 2019 increased by134.3%, 127.69%, and 445.00%, and their corresponding standardized rates increased by 30.53%, 27.03%, and 187.29%,respectively, showing an overall upward trend. Conclusions From 1990 to 2019, the standardized incidence rate and standardized mortality rate of colorectal cancer in China have had a continuously increasing trend, and males and the elderly are high-risk groups. To reduce the burden of colorectal cancer in China, effective measures should be taken for prevention and management.更多还原