【摘要】 目的 :观察阿伐曲泊帕治疗肿瘤化疗所致血小板减少症(chemotherapy-induced thrombocytopenia,CIT)的有效性和安全性。方法 :回顾性收集2020年8月—2020年11月在包括上海市第六人民医院在内的全国20家医院内接受阿伐曲泊帕治疗的CIT患者,纳入化疗后发生≥1级血小板减少症(血小板计数≤100×10~9/L)的患者。研究人员结合患者实际情况,指导患者口服阿伐曲泊帕片剂(20～60)mg/d(20 mg/片)。所有患者至少连续口服阿伐曲泊帕5 d,或达到停药指征(血小板计数≥100×10~9/L或较用药前升高≥50×10~9/L)。记录患者血小板计数的变化。结果 :本研究共纳入101例符合病例选择标准的CIT患者,化疗周期X(接受阿伐曲泊帕治疗的当前化疗周期)内的阿伐曲泊帕升血小板有效率为87.1%(88/101)。不同性别、肿瘤类型、体质指数、TNM分期、肿瘤转移部位、基线血小板计数以及化疗周期数的患者的升血小板有效率差异均无统计学意义(P>0.05)。化疗周期X内,仅1例(1.0%)患者发生出血事件、25例(24.8%)患者接受血小板输注;未发现阿伐曲泊帕相关不良反应的记录。结论 :阿伐曲泊帕治疗CIT的疗效较好且不良事件发生率低,可以建议用于临床治疗CIT。更多还原

【Abstract】 Objective:To observe the efficacy and safety of avatrombopag in treatment of chemotherapy-induced thrombocytopenia(CIT).Methods:This study retrospectively investigated patients with CIT treated by avatrombopag in Shanghai Sixth People’s Hospital and other 19 hospitals in China,from August 2020 to November 2020.Patients with ≥grade 1 thrombocytopenia(platelet count≤100×10~9/L) induced by chemotherapy were included,and the patients were guided to take 20 mg(1 tablet)-60 mg(3 tablets) avatrombopag daily based on their actual conditions.All patients were treated for at least 5 consecutive days unless reaching the withdrawal indication(platelet count≥100×10~9/L or platelet count elevation≥50×10~9/L vs the baseline).The change in platelet count was recorded.Results:A total of 101 eligible patients were recruited,and the efficacy rate of platelet count rising in chemotherapy-cycle X(current chemotherapy cycle receiving avatrombopag) was 87.1%(88/101).There were no significant differences in the response rates of platelet count rising in patients according to different genders,tumor types,body mass index(BMI),TNM stages,tumor metastasis sites,baseline platelet counts,and the number of chemotherapy cycles(P>0.05).cycles(P>0.05).Onlyonepatient(1.0%)developed bleeding events,and 25 patients(24.7%) received platelet transfusion during chemotherapy-cycle X.There were no records of adverse events related to avatrombopag.Conclusion:The efficacy of avatrombopag in the treatment of CIT is favorable with few adverse events,thus avatrombopag could be recommended for CIT in clinical practice.更多还原