【摘要】 目的:分析布地奈德联合硫酸沙丁胺醇治疗咳嗽变异性哮喘患儿的效果及预后情况。方法:选择2018年6月～2019年11月本院收治的108例咳嗽变异性哮喘患儿作为研究对象,采用随机双盲对照法将入组患儿分为对照组和治疗组,各54例。对照组予以布地奈德吸入气雾剂治疗,治疗组在对照组基础上联合硫酸沙丁胺醇吸入气雾剂治疗。观察两组临床疗效、咳嗽评分、嗜酸性粒细胞(EOS)计数、免疫球蛋白E(Ig E)水平、肺功能和复发情况。结果:治疗组总有效率高于对照组(P <0.05)。治疗后,两组日间及夜间咳嗽评分均低于治疗前,且治疗组低于对照组(P <0.05)。治疗后,两组EOS、Ig E水平均低于治疗前,且治疗组低于对照组(P <0.05)。治疗后,两组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC均高于治疗前,且治疗组高于对照组(P <0.05)。两组治疗期间不良反应发生率比较无统计学差异(P>0.05)。随访6个月,治疗组复发率低于对照组(P <0.05)。结论:布地奈德联合硫酸沙丁胺醇能提高咳嗽变异性哮喘患儿的疗效,减轻咳嗽症状,改善肺功能,降低复发率,且安全性较高。更多还原

【Abstract】 Objective: To analyze the effect of budesonide combined with salbutamol sulfate in the treatment of children with cough variant asthma and its influence on prognosis. Methods: A total of 108 children with cough variant asthma admitted to our hospital from June 2018 to November 2019 were selected as the research subjects. A randomized double-blind controlled study method was used to divide the enrolled children into a control group and a treatment group,with 54 cases in each group. The control group was treated with budesonide inhalation aerosol,and the treatment group with additional salbutamol sulfate inhalation aerosol on the basis of the control group. The clinical efficacy of the two groups,cough score,eosinophil( EOS) count,immunoglobulin E( IgE) level,lung function and recurrence were observed. Results: The total effective rate of the treatment group was higher than that of the control group( P < 0. 05). After treatment,the day and night cough scores of the two groups were lower than before treatment,and which was lower in the treatment group than in the control group( P < 0. 05). After treatment,the EOS and IgE levels of the two groups were lower than before treatment,and which was lower in the treatment group than in the control group( P < 0. 05). After treatment,the forced expiratory volume in the first second( FEV1),forced vital capacity( FVC),FEV1/FVC in the two groups were higher than before treatment,and which were higher in the treatment group than in the control group( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the two groups of children during treatment( P > 0. 05). After 6 months of follow-up,the recurrence rate of the treatment group was lower than that of the control group( P < 0. 05).Conclusion: Budesonide combined with salbutamol sulfate can improve the curative effect of children with cough variant asthma,reduce cough symptoms,improve lung function,reduce recurrence rate,and have high safety.更多还原