【摘要】 目的观察补骨汤联合阿仑膦酸钠维D3片治疗肝肾阴虚型骨质疏松症的临床疗效。方法将纳入的60例骨质疏松症患者随机分为对照组和观察组,每组各30例。对照组予以阿仑膦酸钠维D3片口服治疗,观察组在对照组的基础上加用补骨汤治疗,均治疗3个月。观察2组患者治疗前后骨密度、骨转换生化指标、视觉模拟评分法(VAS)评分、中医证候积分的水平变化情况及评价2组患者的临床疗效。结果治疗后,2组患者的骨密度较治疗前明显升高(P<0.05),且观察组的骨密度高于对照组(P<0.05);2组患者的血清Ⅰ型胶原降解产物、Ⅰ型胶原氨基端延长肽、中医证候积分及VAS评分均较治疗前降低(P<0.05),且观察组以上指标水平低于对照组(P<0.05)。观察组总有效率为93.33%(28/30),高于对照组的80.00%(24/30),观察组的临床疗效优于对照组(P<0.05)。结论补骨汤联合阿仑膦酸钠维D3片可有效地改善肝肾阴虚型骨质疏松症患者腰膝酸软、下肢痿弱、步行距离短、目眩及腰背疼痛等临床症状,降低骨折风险,有助于提升患者生活质量。更多还原

【Abstract】 Objective To observe the clinical effect of Bugu decoction combined with alendronate sodium and vitamin D3 tablets on osteoporosis of liver kidney yin deficiency type.Methods 60 patients with osteoporosis were randomly divided into two groups, 30 cases in each group. The control group was given alendronate sodium and vitamin D3 tablets,and the observation group was treated with Bugu decoction on the basis of the control group,both of which were treated for 3 months. The clinical efficacy,bone mineral density,bone turnover markers,VAS score and TCM syndrome score were observed and compared between the two groups.Results After all the treatment, the BMD of lumbar vertebrae and femoral neck in the two groups were increased compared with those before treatment(P<0.05). The increase degree of the observation group was higher than that of the control group(P<0.05). The serum levels of collagen I degradation products, amino terminal elongation peptide of type I collagen,TCM syndrome score and VAS score of the two groups were lower than those before treatment(P<0.05).And the above levels of observation group were lower than those in the control group(P<0.05). The total effective rate of the observation group was 93.33%(28/30),which was higher than that of the control group 80.0%(24/30)and the difference was statistically significant(P<0.05).Conclusion Bugudecoction combined with alendronate sodium and vitamin D3 tablets can effectively improve the clinical symptoms of osteoporosis patients with liver and kidney yin deficiency type,such as weakness in the waist and knees,weak lower limbs,short walking distance,dizziness,and back pain. It is helpful to reduce the risk of fractures and improve the quality of life of patients.更多还原