【摘要】 目的探讨血清半乳糖凝集素-3(Gal-3)与急性心肌梗死(AMI)患者新发心房颤动(AF)的关联性。方法选择2018年10月至2019年12月广西壮族自治区人民医院收治的AMI合并新发AF患者30例(新发AF组),另选同期AMI未合并新发AF患者30例(非AF组)。通过医院病历系统收集两组的临床资料,采用多因素logistic回归分析影响AMI患者新发AF的因素,采用Pearson相关分析探讨Gal-3与B型利钠肽前体(NT-proBNP)、左房前后径的相关性。结果新发AF组左心房前后径、NT-proBNP和血清Gal-3水平高于非AF组,差异有统计学意义(P <0.05)。多因素logistic回归分析结果显示,较高水平的血清Gal-3是促进AMI患者新发AF的危险因素(OR=2.719,P=0.006)。AMI患者的血清Gal-3水平与NT-proBNP水平、左心房前后径呈显著正相关(P <0.05)。结论血清Gal-3水平与AMI患者新发AF密切相关,具有作为预测AMI患者新发AF标志物的潜力。更多还原

【Abstract】 Objective To investigate the association between serum galectin-3( Gal-3) and new-onset atrial fibrillation( AF) in patients with acute myocardial infarction( AMI). Methods From October 2018 to December 2019,30 patients with AMI complicated with new-onset AF who were admitted to the People’s Hospital of Guangxi Zhuang Autonomous Region were selected as the new-onset AF group,and 30 patients with AMI but without new-onset AF during the same period were selected as the non-AF group. The clinical data of the two groups were collected through the hospital medical record system. Multivariate logistic regression analysis was used to analyze the factors influencing new-onset AF in the AMI patients,and Pearson correlation analysis was used to investigate the correlation between Gal-3 and N-terminal prohormone of brain natriuretic peptide( NT-proBNP) and the anteroposterior diameter of the left atrium. Results The anteroposterior diameter of the left atrium,the levels of NT-proBNP and serum Gal-3 in the new-onset AF group were higher than those in the non-AF group,and the differences were statistically significant between the two groups( P <0. 05). The results of multivariate logistic regression analysis showed that a higher level of serum Gal-3 was a risk factor for the development of new-onset AF in the AMI patients( OR = 2. 719,P = 0. 006). The levels of serum Gal-3 in the AMI patients were significantly positively correlated with the levels of NT-proBNP and the anteroposterior diameter of the left atrium( P < 0. 05). Conclusion Serum Gal-3 level is closely related to new-onset AF in patients with AMI,and has the potential to be used as a marker for predicting new-onset AF in AMI patients.更多还原