【摘要】 目的分析暴发性1型糖尿病(FT1DM)的临床特征,提高临床医师对FT1DM的认识。方法收集2003年10月至2019年12月广西医科大学第九附属医院收治的15例FT1DM患者的临床资料,另选择同期49例非暴发性1型糖尿病(NFT1DM)患者的临床资料进行分析。根据病程、餐后C肽(PCP)、糖化血红蛋白(Hb A1c)水平,将NFT1DM患者分为短病程NFT1DM组(25例)、长病程NFT1DM组(24例);低C肽NFT1DM组(27例)、高C肽NFT1DM组(22例);低Hb A1c NFT1DM组(7例)、高Hb A1c NFT1DM组(42例)。对各组间的临床指标进行比较。结果与NFT1DM组比较,FT1DM组年龄更大,病程更短,Hb A1c、空腹C肽(FCP)、PCP水平更低,而血糖、血清肌酐(Scr)、血尿素氮(BUN)、血钾水平更高,差异有统计学意义(P <0.05)。FT1DM组、短病程NFT1DM组和长病程NFT1DM组在年龄、Hb A1c、FCP、PCP、Scr、BUN和血钾方面比较差异有统计学意义(P <0.05)。FT1DM组、低C肽NFT1DM组和高C肽NFT1DM组在病程、血糖、Hb A1c、FCP、Scr、BUN和血钾方面比较差异有统计学意义(P <0.05)。FT1DM组、低Hb A1c NFT1DM组和高Hb A1c NFT1DM组在年龄、病程、FCP、PCP、Scr、BUN和血钾方面比较差异有统计学意义(P <0.05)。结论与NFT1DM相比,FT1DM有其特点。FT1DM的诊断分类值得进一步讨论。更多还原

【Abstract】 Objective To analyze the clinical feature of fulminant type 1 diabetes mellitus( FT1 DM),and to improve clinicians’ understanding of FT1 DM. Methods The clinical data of 15 patients with FT1 DM admitted to the Ninth Affiliated Hospital of Guangxi Medical University from October 2003 to December 2019 were collected,and the clinical data of 49 patients with non-fulminant type 1 diabetes mellitus( NFT1 DM) during the same period were selected for analysis. The NFT1 DM patients were divided into short-course NFT1 DM group( 25 cases) and long-course NFT1 DM group( 24 cases) according to the course of the disease,and were divided into low C-peptide NFT1 DM group( 27 cases)and high C-peptide NFT1 DM group( 22 cases) according to the levels of postprandial C-peptide( PCP),and were divided into low glycated hemoglobin A1 c( Hb A1 c) NFT1 DM group( 7 cases) and high Hb A1 c NFT1 DM group( 42 cases)according to the levels of Hb A1 c. The clinical indicators were compared among the groups. Results Compared with the NFT1 DM group,the FT1 DM group was older,and had a shorter course of the disease,lower levels of Hb A1 c,fasting plasma C-peptide( FCP) and PCP,and higher levels of blood sugar,serum creatinine( Scr),blood urea nitrogen( BUN)and blood potassium,and the differences were statistically significant between the two groups( P < 0. 05). There were statistically significant differences in age,Hb A1 c,FCP,PCP,Scr,BUN and serum potassium among the FT1 DM group,the short-course NFT1 DM group and the long-course NFT1 DM group( P < 0. 05). There were statistically significant differences in the course of the disease,blood sugar,Hb A1 c,FCP,Scr,BUN and serum potassium among the FT1 DM group,the low C-peptide NFT1 DM group and the high C-peptide NFT1 DM group( P < 0. 05). There were statistically significant differences in age,the course of the disease,FCP,PCP,Scr,BUN and serum potassium among the FT1 DM group,the low Hb A1 c NFT1 DM group and the high Hb A1 c NFT1 DM group( P < 0. 05). Conclusion Compared with NFT1 DM,FT1 DM has its characteristics. The diagnostic classification of FT1 DM deserves further discussion.更多还原