【摘要】 肝癌的复发转移是影响肝癌患者预后的关键。血管包绕肿瘤细胞巢(VETC)癌巢型肝细胞癌的转移方式无法用上皮-间质转化(EMT)理论来解释,其可以内皮细胞包绕肿瘤细胞团的形式发生整体转移,转移过程中肿瘤细胞不会发生EMT,VETC癌巢型肝细胞癌更易发生转移,转移效率更高,术后更易复发,预后更差。该文对VETC癌巢型肝细胞癌的分型、分子学特征、诊断、治疗及预后等进行评价和介绍,从而提高临床医师及研究人员对该类肝癌诊治的认识。更多还原

【Abstract】 Relapse and metastasis are the key factors affecting the prognosis of patients with hepatocellular carcinoma( HCC). The metastasis mechanisms of vessels encapsulated tumor clusters( VETC) carcinoma nest-type HCC can not be explained by the theory of epithelial-to-mesenchymal transition( EMT). In VETC carcinoma nest-type HCC,tumor cells do not metastasize through EMT,but metastasize to other organs in carcinoma nest form in which VETC carcinoma nest-type HCC is encapsulated by endothelial cells. VETC carcinoma nest-type HCC is more likely to have metastasis and higher metastatic efficiency,and is more likely to relapse after operation,resulting in a worse prognosis. This paper evaluates and introduces the classification,molecular characteristics,diagnosis,treatment and prognosis of VETC carcinoma nest-type HCC,so as to improve the understanding of clinicians and researchers on the diagnosis and treatment of VETC carcinoma nest-type HCC.更多还原