【摘要】 目的观察柴胡利胆颗粒治疗急性胆囊炎的临床疗效并探讨其作用机制。方法 140例患者随机分为治疗组与对照组各70例。对照组给予西医常规治疗,治疗组在对照组基础上加用柴胡利胆颗粒治疗。两组疗程均为3 d。结果治疗组总有效率为91.43%,高于对照组的64.29%(P <0.05)。两组治疗前C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平比较,均差别不大(均P> 0.05)。两组治疗后CRP、TNF-α、IL-8水平均较治疗前下降(均P <0.05),且治疗组治疗后CRP、TNF-α、IL-8水平均低于对照组(均P <0.05)。治疗组临床症状如发热、疼痛、恶心、呕吐等缓解时间均短于治疗组(均P <0.05)。两组治疗前血浆CRP、白细胞计数(WBC)、NEUT水平比较,均差别不大(均P> 0.05)。两组治疗后血浆CRP、WBC、NEUT水平均较治疗前改善(均P <0.05),且治疗组改善均优于对照组(均P <0.05)。两组治疗前胁痛、发热、黄疸、舌脉症状评分比较,均差别不大(均P> 0.05)。两组治疗后3、7、14 d胁痛、发热、黄疸、舌脉症状评分较治疗前均下降(均P <0.05),且治疗组治疗同期胁痛、发热、黄疸、舌脉症状评分均低于对照组(P <0.05)。治疗组不良反应发生率低于对照组(P <0.05)。结论中西医结合治疗急性胆囊炎疗效更好、更快,柴胡利胆颗粒为临床治疗急性胆囊炎的有效方剂。更多还原

【Abstract】 Objective:To observe the clinical efficacy of Chaihu Lidan Granules in the treatment of acute cholecystitis. Methods:A total of 140 cases of acute cholecystitis were divided into the treatment group and control group,70 cases in each group. The control group was treated by western medicine,and the treatment group was treated by Chaihu Lidan Granules. The course of treatment in both groups was 3 d. Results:The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P < 0.05). After treatment,the levels of CRP,TNF-α,and IL-8 in the two groups were significantly lower than before treatment(P < 0.05),and the levels of CRP,TNF-α,and IL-8 in the observation group were significantly lower than those in the control group(P < 0.05). After treatment,the scores of hypochondriac pain,fever,jaundice,tongue and pulse symptoms in the two groups were significantly lower than those before treatment(P < 0.05),and the scores of hypochondriac pain,fever,jaundice,and tongue and pulse symptoms in the observation group were significantly lower than those in the control group(P < 0.05);the remission time of clinical symptoms such as fever,pain,nausea,and vomiting in the treatment group was significantly shorter than that in the treatment group(P <0.05);CRP,WBC,and NEUT levels after treatment in the two groups were improved compared to before treatment(P < 0.05),and the treatment group improved more significantly(P < 0.05);the incidence of adverse reactions in the treatment group was also lower than that in the control group,and the difference between was statistically significant(P < 0.05). Conclusion:Traditional Chinese combined with western medicine has a better and faster curative effect on acute cholecystitis. Chaihu Lidan Granules is an effective prescription for clinical treatment of acute cholecystitis,which is worthy of clinical promotion.更多还原