【摘要】 目的:探讨低分子量肝素钠联合乌司他丁治疗高脂血症性胰腺炎的效果。方法:选择本院消化内科2019年5月-2021年5月收治的48例高脂血症性胰腺炎患者,依照随机数字表法将患者分为对照组(n=24)与研究组(n=24)。两组均进行常规治疗,在此基础上,对照组应用低分子量肝素钠治疗,研究组应用低分子量肝素钠联合乌司他丁治疗。比较两组实验室血清学指标、APPACHEⅡ评分与CTSI评分、相关预后指标、并发症发生情况。结果:治疗前,两组的实验室血清学指标水平比较,差异均无统计学意义(P>0.05);治疗48、72 h后,两组氧合指数(OI)均高于治疗前,其他实验室血清学指标水平均低于治疗前,差异均有统计学意义(P<0.05);治疗48、72 h后,研究组的OI高于对照组,其他的实验室血清学指标均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组的APACHEⅡ评分与CTSI评分对比,差异均无统计学意义(P>0.05);治疗72 h后,两组的APACHEⅡ评分和CTSI评分均低于治疗前,差异均有统计学意义(P<0.05);治疗72 h后,研究组的APACHEⅡ评分和CTSI评分均低于对照组,差异均有统计学意义(P<0.05)。研究组的恢复排气时间、腹痛缓解时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:低分子量肝素钠联合乌司他丁治疗高脂血症性胰腺炎的效果理想,能够有效促进患者病情康复,取得良好预后,可在临床推广应用。更多还原

【Abstract】 Objective:To explore the effect of Low Molecular Weight Heparin Sodium combined with Ulinastatin in the treatment of hyperlipidemia pancreatitis.Method:A total of 48 patients with hyperlipidemic pancreatitis admitted to department of gastroenterology of our hospital from May 2019 to May 2021 were selected and divided into control group (n=24) and study group (n=24) according to random number table method.Both groups received conventional treatment,on this basis,the control group was treated with Low Molecular Weight Heparin Sodium,and the study group was treated with Low Molecular Weight Heparin Sodium combined with Ulinastatin.Laboratory serological indexes,APACHEⅡ and CTSI scores,related prognostic indexes and complications were compared between the two groups.Result:Before treatment,there were no significant difference in laboratory serological indexes between the two groups (P>0.05);after 48 and 72 h of treatment,oxygenation index (OI) of two groups were higher than those before treatment,and other laboratory serological indexes were lower than those before treatment,the differences were statistically significant (P<0.05);after 48 and 72 h of treatment,the OI of the study group were higher than those of the control group,and other laboratory serological indexes were lower than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no statistical significances in APACHEⅡ score and CTSI score between two groups (P>0.05);after 72 h of treatment,the APACHEⅡ scores and CTSI scores in two groups were lower than those before treatment,the differences were statistically significant (P<0.05);after 72 h of treatment,the APACHEⅡ score and CTSI score of the study group were lower than those of the control group,the differences were statistically significant (P<0.05).The recovery time of exhaust,abdominal pain relief time and hospital stay time in the study group were shorter than those in the control group,the differences were statistically significant (P<0.05).The complication rate in the study group was lower than that in the control group,the difference was statistically significant (P<0.05).Conclusion:Low Molecular Weight Heparin Sodium combined with Ulinastatin has an ideal effect in the treatment of hyperlipidemic pancreatitis,which can effectively promote the recovery of patients and achieve a good prognosis,it can be popularized in clinical application.更多还原