【摘要】 目的:探讨乙型肝炎病毒(HBV)相关慢加急性肝衰竭(ACLF)血清甲胎蛋白(AFP)、高尔基体蛋白73(GP73)的表达与疾病预后关系。方法:回顾性分析2016年1月至2020年HBV-ACLF患者与慢性乙型肝炎(CHB)患者各60例临床资料,并选择同期体检的60例健康人员作为对照组,比较3组人群血清AFP、GP73的表达,并比较HBV-ACLF组不同病情程度及预后患者血清AFP、GP73表达水平差异。结果:HBV-ACLF组患者血清AFP、GP73分别为(179.02±14.51)ng/ml、(271.34±20.91)ng/ml, CHB组患者为(41.52±3.86)ng/ml、(110.04±15.32)ng/ml,对照组人群为(5.02±2.73)ng/ml、(36.86±3.04)ng/ml, HBV-ACLF组和CHB组患者血清AFP、GP73水平均明显高于对照组人群(P<0.05),且HBV-ACLF组明显高于CHB组(P<0.05)。随着HBV-ACLF患者病程程度的加重,血清AFP水平逐渐降低,GP73水平逐渐升高(P<0.05);HBV-ACLF生存组患者血清AFP水平明显高于死亡组(P<0.05),GP73水平明显低于死亡组(P<0.05);Logistic回归分析显示,血清AFP、GP73均是影响预后的独立危险因素(P<0.05)。结论:血清AFP、GP73在HBV-ACLF患者中均呈明显升高状态,且是影响预后的独立危险因素。更多还原

【Abstract】 Objective:To study the expression of serum alpha fetoprotein(AFP) and golgi protein 73(GP73) in patients with hepatitis B virus(HBV) related acute and chronic liver failure(ACLF) and the relationship with prognosis.Methods:The clinical data of 60 patients with HBV-ACLF and 60 patients with chronic hepatitis B(CHB) admitted from January 2016 to 2020 were retrospectively analyzed, and 60 healthy individuals in our hospital during the same period were selected as the control group, the expression of serum AFP and GP73 were compared among the three groups, and the expression of AFP and GP73 in patients with different degrees of disease and prognosis in HBV-ACLF group were compared. Results:The serum AFP and GP73 in HBV-ACLF group were(179.02±14.51)ng/ml,(271.34±20.91)ng/ml, in the CHB group were(41.52±3.86)ng/ml,(110.04±15.32)ng/ml, in the control group were(5.02±2.73)ng/ml,(36.86±3.04)ng/ml, the serum AFP and GP73 of HBV-ACLF group and CHB group were significantly higher than control group(P<0.05), and HBV-ACLF group was significantly higher than CHB group(P<0.05); with the aggravation of the course of HBV-aclf, the serum AFP level gradually decreased and the GP73 level increased gradually(P<0.05); and the serum AFP in survival group was significantly higher than the death group, and GP73 was significantly lower than the death group(P<0.05); the Logistic regression analysis showed that serum AFP and GP73 were independent risk factors for prognosis(P<0.05). Conclusion:The serum AFP and GP73 are significantly increased in patients with HBV-ACLF, and it’s an independent risk factor for prognosis.更多还原