【摘要】 系统性硬化症 (SSc)是一种罕见且累及全身多脏器的自身免疫性疾病。其病因和发病机制复杂,目前多以对症治疗为主。随着对干细胞研究的不断探索,干细胞治疗在医学领域的价值日益突显。越来越多的证据表明干细胞作为一种具有强大分化及再生潜能的有效手段在SSc患者的治疗中逐渐呈现出良好的效果。本文主要对3种常见来源的人间充质干细胞 (hMSCs)包括骨髓hMSCs、脂肪hMSCs和脐带hMSCs在SSc患者中治疗的研究进展进行比较及展望,旨在为SSc患者的治疗提供更多依据。更多还原

【Abstract】 Systemic sclerosis (SSc) is a rare autoimmune disease that affects multiple organs throughout the body.Due to a poor understanding of the etiology and pathogenesis of SSc,at present,symptomatic treatment is commonly used.With the continuous exploration of stem-cell research,the value of stem cell therapy in the medical field is increasingly highlighted.There is increasing evidence to suggest that stem cells as an effective means with strong differentiation and regenerative potential gradually show good results in the treatment of SSc patients.In this review,in order to provide a more solid basis,we compared and looked forward to the research progress in three common sources of human mesenchymal stem cells (hMSCs) including bone marrow hMSCs,adipose-derived hMSCs and umbilical cord-derived hMSCs in the treatment of patients with SSc.更多还原