【摘要】 目的系统评估超声引导下注射肉毒杆菌毒素(BoNT)对局部疼痛(神经疼痛和关节痛等)患者疗效的影响。方法计算机检索Pubmed、Embase、Web of Science、Scopus、中国知网、维普及万方数据库从建库至2020年2月发表的关于超声引导下注射BoNT治疗局部疼痛患者的文献。由2位研究者按照纳入和排除标准对相关文献独立进行文献筛选及数据提取,使用STATA 12.0软件进行Meta分析。结果共纳入7篇文献,包含115例患者。Meta分析结果显示,与治疗前比较,局部疼痛患者在超声引导下注射BoNT治疗后1个月[加权平均差(WMD)=3.68,95%置信区间(CI)(2.37,5.00),Z=5.50,P <0.001]、3个月[WMD=4.09,95%CI(1.85,6.34),Z=3.58,P <0.001]及6个月[WMD=5.29,95%CI(3.27,7.30),Z=5.15,P <0.001]视觉模拟量表评分均显著降低。结论超声引导下注射BoNT可以有效缓解患者的神经性疼痛和关节疼痛。更多还原

【Abstract】 Objective To systemically evaluate the effect of botulinum toxin(BoNT injection for regional pain(neuropathic and joint pain) by ultrasonography. Methods The articles about BoNT injection for patients with regional pain by ultrasonography were searched in Pubmed, Embase, Web of Science, Scopus, CNKI, VIP and Wanfang databases published up to February 2020. Two reviewers independently screened articles and extracted data according to inclusion and exclusion criteria. The STATA 12.0 software was used to perform meta-analysis.Results A total of seven studies with 115 patients were included. Meta-analysis demonstrated that the visual analogue scale scores at one month [weighted mean difference(WMD) = 3.68,95% confidence interval(CI)(2.37, 5.00), Z = 5.50, P < 0.001], there months [WMD = 4.09, 95%CI(1.85, 6.34), Z = 3.58, P < 0.001] and six months [WMD = 5.29, 95%CI(3.27, 7.30), Z = 5.15,P < 0.001] after BoNT injection by ultrasonography were much lower than those before the treatment in patients with regional pain. Conclusion The BoNT injection by ultrasonography can effectively relieve patients’ neuropathic and joint pain.更多还原