【摘要】 目的分析给予老年急性ST段抬高型心肌梗死患者替格瑞洛片联合阿司匹林肠溶片治疗的效果。方法 108例老年急性ST段抬高型心肌梗死患者,运用随机数字表法分成观察组和参照组,各54例。参照组采取硫酸氢氯吡格雷片联合阿司匹林肠溶片进行治疗,观察组采取替格瑞洛片联合阿司匹林肠溶片进行治疗。比较两组患者的心血管不良事件发生情况,治疗前后的血小板功能指标(血小板聚集率、P2Y12反应单位)及心功能指标[左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)]。结果观察组患者的心血管不良事件发生率5.56%低于参照组的18.52%,差异具有统计学意义(P<0.05)。治疗后,观察组患者血小板聚集率(35.47±2.87)%、P2Y12反应单位(142.38±9.87)U低于参照组的(37.28±2.28)%、(147.28±9.06)U,差异具有统计学意义(P<0.05)。治疗后,观察组患者的LVEF(52.87±6.76)%高于参照组的(49.57±6.41)%, LVESV(101.25±5.61)ml、LVEDV(114.16±2.65)ml低于参照组的(114.76±5.78)、(121.72±2.86)ml,差异具有统计学意义(P<0.05)。结论在老年急性ST段抬高型心肌梗死的临床治疗中,应用替格瑞洛片联合阿司匹林肠溶片治疗的效果更为显著,可降低心血管不良事件的发生风险,有效改善血小板功能与心功能,对改善疾病预后具有重要作用。更多还原

【Abstract】 Objective To analyze the effect of ticagrelor tablets combined with aspirin enteric-coated tablets on elderly patients with acute ST segment elevation myocardial infarction. Methods 108 elderly patients with acute ST segment elevation myocardial infarction were randomly divided into observation group and control group, with 54 cases in each group. Patients in the control group were administrated with clopidogrel bisulfate tablets combined with aspirin enteric-coated tablets, while patients in the observation group were administrated with ticagrelor tablets combined with aspirin enteric-coated tablets. The incidence of cardiovascular adverse events, platelet function indicators(platelet aggregation rate, P2 Y12 response unit) and cardiac function indicators [left ventricular ejection fraction(LVEF), left ventricular end systolic volume(LVESV), left ventricular end diastolic volume(LVEDV)] before and after treatment were compared between the two groups. Results The incidence of cardiovascular adverse events of the observation group was 5.56%, which was lower than 18.52% of the control group, and the difference was statistically significant(P<0.05). After the treatment, the observation group had a platelet aggregation rate of(35.47±2.87)% and P2Y12 response unit of(142.38±9.87) U, which were lower than(37.28±2.28)% and(147.28±9.06) U of the control group, respectively, and the differences were statistically significant(P<0.05). After treatment, LVEF of the observation group was(52.87±6.76)%, which was higher than(49.57±6.41)% of the control group; LVESV and LVEDV of the observation group were(101.25±5.61)and(114.16±2.65) ml, which were lower than(114.76±5.78) and(121.72±2.86) ml of the control group,respectively; and the differences were statistically significant(P<0.05). Conclusion In the clinical treatment of elderly patients with acute ST segment elevation myocardial infarction, the effect of ticagrelor tablets combined with aspirin enteric-coated tablets was more significant, with a risk reduction of cardiovascular adverse events, an effective improvement of platelet function and cardiac function. Hence, it plays an important role in improving the prognosis of the disease.更多还原