【摘要】 小檗碱(Berberine)是一种从中药黄连中分离的异喹啉生物碱,具有杀菌、杀虫和除草活性。本研究采用挤压造粒法制备小檗碱可溶性粒剂,通过单因素试验对载体、分散剂、润湿剂、结剂、崩解剂等主要助剂的种类和用量进行筛选,结果发现,30%小檗碱可溶性粒剂研制的最佳配方为30%小檗碱、10%木质素磺酸钠、7%聚羧酸sp-2845w、2%聚乙烯醇盐、7%氯化钠和44%无水硫酸钠。进一步通过室内土壤处理法对狗尾草Setaria viridis L.进行防治试验,结果表明30%硫酸小檗碱可溶性粒剂的防治效果显著性优于30%盐酸小檗碱可溶性粒剂,其在弱碱性条件下(pH值为9),3,7,14d的防效分别为74.24%,66.01%和68.17%,而且显著性抑制狗尾草的生长。更多还原

【Abstract】 Berberine,an isoquinoline alkaloid isolated from the traditional Chinese medical plant Coptis chinensis,exhibits bactericidal,insecticidal and herbicidal activity.In order to provide theoretical support and technical guidance for the production of berberine-base pesticides,soluble granules were prepared using extrusion granulation.Through single-factor screening tests,the types and amounts of major additives(carriers,dispersants,wetting agents,binders and disintegrators)were screened and optimized.The optimized formulation of the obtained 30% berberine soluble granules was found to be 30% berberine +10% sodium ligninsulfonate +7% polycarboxylate sp-2845 w +2% polyvinyl alcohol-vinylalcohol polymer +7%NaCl+44% anhydrous Na2 SO4.Furthermore,the indoor soil treatment method was used to control green bristlegrass(Setaria viridis L.).The results showed that the control effect of 30% berberine sulfate soluble granule was significantly better than that of 30% berberine hydrochloride soluble granule.Under the condition of weak alkalinity(pH=9),the control effects were 74.24%,66.01%and 68.17%for 3,7 and14 days,respectively,and significantly inhibited the growth of green bristlegrass.更多还原