【摘要】 目的研究早期机械通气治疗重型颅脑损伤的临床疗效。方法 42例重型颅脑损伤患者,采用随机数字表法分为对照组和观察组,每组21例。两组患者均行常规治疗,对照组患者发生呼吸衰竭症状时给予机械通气治疗,观察组患者入院后即给予机械通气治疗。比较两组患者治疗前后血氧饱和度、氧分压、二氧化碳分压及重症加强护理病房(ICU)住院时间、预后情况。结果治疗前,两组血氧饱和度、氧分压、二氧化碳分压比较差异无统计学意义(P>0.05);治疗后,两组血氧饱和度、氧分压均高于本组治疗前,二氧化碳分压低于本组治疗前,且观察组血氧饱和度、氧分压高于对照组,二氧化碳分压低于对照组,差异具有统计学意义(P<0.05)。观察组ICU住院时间为(6.53±1.02)d,短于对照组的(10.14±1.13)d,差异具有统计学意义(t=10.867, P=0.000<0.05)。观察组预后良好率61.90%高于对照组的14.29%,重度残疾率9.52%低于对照组的38.10%,差异具有统计学意义(P<0.05)。结论早期机械通气治疗重型颅脑损伤的优势显著,可改善患者的血气指标,缩短ICU住院时间,且预后良好,值得临床推广应用。更多还原

【Abstract】 Objective To study the clinical efficacy of early mechanical ventilation on prognosis of patients with severe craniocerebral injury. Methods A total of 42 patients with severe craniocerebral injury were divided into control group and observation group according to random numerical table, with 21 cases in each group. Both groups underwent conventional treatment. Patients in the control group were treated with mechanical ventilation when they developed symptoms of respiratory failure, and patients in the observation group were treated with mechanical ventilation after admission. The blood oxygen saturation, oxygen partial pressure, carbon dioxide partial pressure before and after treatment and hospitalization time in the intensive care unit(ICU) and prognosis of the two groups were compared. Results Before treatment, there was no statistically significant difference in blood oxygen saturation, oxygen partial pressure and carbon dioxide partial pressure between the two groups(P>0.05). After treatment, the blood oxygen saturation and oxygen partial pressure of the two groups were higher than those before treatment, and carbon dioxide partial pressure was lower than that before treatment. The blood oxygen saturation and oxygen partial pressure of the observation group were higher than those of the control group, and carbon dioxide partial pressure was lower than that of the control group. All the difference was statistically significant(P<0.05). The hospitalization time in ICU of the observation group was(6.53±1.02) d, which was shorter than(10.14±1.13) d of the control group, and the difference was statistically significant(t=10.867, P=0.000<0.05). The good prognosis rate 61.90% of the observation group was higher than 14.29% of the control group, and severe disability rate 9.52% was lower than 38.10% of the control group. All the difference was statistically significant(P<0.05). Conclusion Early mechanical ventilation has a significant advantage in the treatment of severe craniocerebral injury, which can improve the blood gas index of patients, shorten the hospitalization time in ICU, and the prognosis is good, so it is worth popularizing and applying.更多还原