【摘要】 目的观察2HRZE/6HRE(H:异烟肼;R:利福平;Z:吡嗪酰胺;E:乙胺丁醇)方案联合口服链霉素治疗肠结核的疗效。方法 58例肠结核患者,随机分为观察组(28例)与对照组(30例)。对照组接受2HRZE/6HRE抗结核治疗,观察组在对照组基础上联合口服链霉素治疗。比较两组患者临床治疗效果,治疗前后白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平,药物不良反应发生情况。结果治疗后,观察组临床总有效率96.4%(27/28)明显高于对照组的73.3%(22/30),差异有统计学意义(P<0.05)。治疗前,观察组WBC(12.90±2.63)×10~9/L、CRP(59.97±52.01)mg/L、PCT(1.26±0.92)ng/L与对照组的(12.64±3.87)×10~9/L、(57.69±56.95)mg/L、(1.15±0.77)ng/L比较,差异均无统计学意义(P>0.05)。治疗后,观察组WBC(6.74±1.81)×10~9/L、CRP(13.36±13.20)mg/L、PCT(0.31±0.36)ng/L均明显低于对照组的(8.47±1.14)×10~9/L、(32.85±28.10)mg/L、(0.72±0.44)ng/L,差异均有统计学意义(P<0.05)。两组患者药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论 2HRZE/6HRE方案联合口服链霉素治疗肠结核,临床症状改善效果明显,不良反应少。更多还原

【Abstract】 Objective To observe the efficacy of 2HRZE/6HRE(H: isoniazid; R: rifampicin; Z: pyrazinamide; E: ethambutol) regimen combined with oral streptomycin in the treatment of intestinal tuberculosis. Methods A total of 58 patients with intestinal tuberculosis were randomly divided into observation group(28 cases) and control group(30 cases). The control group received 2 HRZE/6 HRE anti-tuberculosis treatment, and the observation group received oral streptomycin on the basis of the control group. The clinical effect, white blood cell count(WBC), C-reactive protein(CRP), procalcitonin(PCT) levels before and after treatment, and the occurrence of adverse drug reactions were compared between the two groups. Results After treatment, the clinical total effective rate 96.4%(27/28) of the observation group was obviously higher than 73.3%(22/30) of the control group, and the difference was statistically significant(P<0.05). Before treatment, the WBC(12.90±2.63)×10~9/L, CRP(59.97±52.01) mg/L and PCT(1.26±0.92) ng/L of the observation group had no statistically significant difference compared with(12.64±3.87)×10~9/L,(57.69±56.95) mg/L and(1.15±0.77) ng/L of the control group(P>0.05). After treatment, the WBC(6.74±1.81)×10~9/L, CRP(13.36±13.20) mg/L and PCT(0.31±0.36) ng/L of the observation group were obviously lower than(8.47±1.14)×10~9/L,(32.85±28.10) mg/L and(0.72± 0.44) ng/L of the control group, and the difference was statistically significant(P<0.05). There was no statistically significant difference in incidence of adverse drug reactions between the two groups(P>0.05). Conclusion The 2 HRZE/6 HRE regimen combined with oral streptomycin can obvious improve the clinical symptoms of patients with intestinal tuberculosis with few adverse reactions更多还原