【摘要】 目的分析脑梗死患者发生阿司匹林耐药与年龄及用药维持期相关性.方法选择250例脑梗死患者为研究对象,其中每个年龄段各选择50例,且每个年龄段的患者均连续服用阿司匹林,100 mg/d,记录不同服药时间(1、2、4、5 a)各年龄段患者尿11-脱氢-血栓素B2的检测结果,最终依据检测结果将其分成阿司匹林耐药组(AR组)和阿司匹林有效组.结果不同年龄及用药维持期患者随着年龄的增长耐药率也增加(P<0.05);同一个年龄段的患者在不同用药维持期其耐药率均随着服用时间的延长而增加,但差异均无统计学意义(P>0.05).结论不同年龄段脑梗死患者与阿司匹林耐药存在一定关联,年龄是其独立的危险因素;在服用阿司匹林相同的时间下,不同年龄段患者与发生AR的概率呈正相关.更多还原

【Abstract】 Objective To analyze correlation between Aspirin resistance and taking time in patients with cerebral infarction.Method 250 patients were selected as subjects, 50 cases are selected for each age group, have taken Aspirin 100 mg/d continuously.The time of taking drug is recorded(1 a, 2 a, 4 a, 5 a)and then recorded different medications.According to the results of urine 11-dehydro-thromboxane B2 test, finally they were divided into Aspirin resistance group(AR Group) and Aspirin effective group.Results Drug resistance rate of patients at different ages increases with age, and the difference was statistically significant(P<0.05).The resistance rate of patients in the same age group after taking different times of Aspirin increased with the prolongation of taking time, but the difference was not statistically significant(P>0.05).Conclusion Patients with cerebral infarction at different ages have a certain correlation with Aspirin resistance, age is an independent risk factor.Under the same time of taking Aspirin, patients of different ages are positively correlated with the probability of AR,ie, the older the age.更多还原