【摘要】 自噬作为一种重要的胞内代谢途径,已被证实普遍存在于多种细胞中,其功能的异常易引发癌症、肝病、糖尿病和心脏病等疾病。自噬在T淋巴细胞自身发育分化及调节T淋巴细胞免疫功能方面也扮演着重要角色,T淋巴细胞自噬异常会造成其免疫功能紊乱进而引发炎症、感染和自身免疫性等疾病。鉴于自噬在调控T淋巴细胞功能和疾病发生发展中的重要作用,本文重点阐述自噬调控T淋巴细胞稳态、存活、增殖、衰老、代谢、免疫功能,以及在包括肿瘤在内的多种疾病发生发展中作用的研究进展。更多还原

【Abstract】 Autophagy, as an important intracellular metabolic pathway, has been proved to be ubiquitous in many kinds of cells. Its functional impairment can easily cause lots of diseases, such as cancer, leukemia, liver disease, diabetes and heart disease. In particular,autophagy is important for the development, differentiation and regulation of immune function of T lymphocytes. Abnormal autophagy of T lymphocytes can cause immune dysfunction and lead to diseases, such as inflammation, infection and autoimmunity. In view of the important role of autophagy in regulating T lymphocyte function and disease, this article illustrates the research progress on autophagy regulating the homeostasis, survival, proliferation, senescence, metabolism, immune function of T lymphocytes and many diseases,including tumors, in recent years.更多还原