【摘要】 心力衰竭(简称心衰)发病率及患病率随年龄增加而逐渐升高,研究显示增龄可独立于其他疾病造成心肌损伤,最终导致心衰发生。本文综述了增龄导致心脏的结构、功能及表型变化,着重叙述了增龄导致心衰的机制研究进展,包括心肌细胞衰老、血管衰老、细胞外基质重塑、神经内分泌失衡及非编码RNA改变等,并介绍了几种针对增龄性心衰的新兴治疗措施。更多还原

【Abstract】 The incidence and prevalence of heart failure(HF) gradually increase with age. Studies have shown that aging can cause myocardial injury independent of other diseases and eventually lead to HF. This article reviews structural, functional and phenotypic changes of heart caused by aging with emphasis on the research progress in the mechanism of HF caused by aging, including cardiomyocyte senescence, vascular senescence, extracellular matrix remodeling, neuroendocrine imbalance, and non-coding RNA changes. It also introduces several new therapeutic measures for aging-related HF.更多还原