【摘要】 代谢综合征是一组表型复杂的代谢紊乱症候群,发病率居高不下。代谢性综合征病理相关的肥胖、胰岛素抵抗、糖尿病、高血压及脂代谢异常促进心血管过早老化。自噬溶酶体途径可降解心血管老化过程中产生的功能异常的蛋白质和细胞器,参与代谢综合征相关的心血管过早老化的发生发展。为寻找各种代谢性疾病下心血管老化治疗的新策略,掌握代谢应激情况下自噬参与心血管过早老化的调节机制异常重要。本文就国际国内前沿简要综述自噬在代谢综合征相关的心血管老化中的作用机制,试图为延缓心血管过早老化及改善其功能异常提供新的理论基础。更多还原

【Abstract】 Metabolic syndrome is a complexity of metabolic derangement with quite high and ever-rising prevalence. Its related diseases, such as obesity, insulin resistance, diabetes, hypertension, and dyslipidemia, all contribute to premature cardiovascular aging. Autophagy-lysosomal pathways represent the major cellular machineries for degradation and removal of damaged or long-lived proteins and organelles produced during the process of cardiovascular aging, and take part in the occurrence and development of premature cardiovascular aging which is associated with metabolic syndrome. To investigate new therapeutic avenue for premature cardiovascular aging under diversified metabolic abnormalities, it is of great importance to grasp the accurate role of autophagy in regulation of the process. In the article, we briefly review the integral role of autophagy in premature cardiovascular aging based on the present domestic and abroad researches at home and abroad in order to provide a new theoretical basis for delaying premature cardiovascular aging and improving the dysfunction of cardiovascular system.更多还原