【摘要】 目的非肌层浸润性膀胱癌(NMIBC)主要由三种不同类型的肿瘤组成:乳头状尿路上皮癌局限于黏膜层(Ta),高级别原位癌局限于上皮层(CIS)以及侵犯黏膜下层或固有层的肿瘤(T1)。NMIBC的首选治疗方案是彻底的经尿道膀胱肿瘤电切术(TURBT)和(或)膀胱灌注治疗。但是,仍有部分高危患者具有肿瘤进展的风险,因而需要接受更积极地治疗策略。有研究报道延迟的全膀胱切除术会导致生存获益显著降低,因此对于这些具有疾病进展高危风险的NMIBC患者,选择在何时放弃传统治疗转而接受全膀胱切除术是当前外科医生面临的一个重大挑战。本文综述了当前全膀胱切除术作为初始治疗在NMIBC患者中的应用现状和未来方向。更多还原

【Abstract】 Nonmuscle invasive bladder cancer (NMIBC) is mainly composed of three different types of tumors:papillary urothelial carcinoma is limited to the mucosal layer (Ta),high-grade carcinoma in situ is limited to the epithelial layer (CIS) and tumors invading the submucosa or lamina propria (T1).The standard treatment for NMIBC is complete transurethral resection of bladder tumors (TURBT) with or without intravesical instillation therapies.However,some high-risk patients are at risk of tumor progression and therefore require more aggressive treatment.Studies have reported that delayed cystectomy can lead to a significant reduction in survival benefits.Therefore,for these NMIBC patients who are at high risk of disease progression,when to abandon conservative treatment and choose cystectomy is one of the biggest challenges.This article reviews the current application status and future directions of radical cystectomy as the initial treatment on NMIBC patients.更多还原