【摘要】 目的探讨结直肠神经内分泌癌(NEC)患者临床病理特征与预后的关系。方法选取2012年1月1日至2020年7月31日在浙江省肿瘤医院接受手术治疗且术后病理证实为结直肠NEC的28例患者为研究对象,分析其临床病理特征与预后的关系。结果就诊时是否发生转移以及不同肿瘤类型、Ki-67增殖指数的患者术后3年累计生存率比较,差异均有统计学意义(均P<0.05);不同性别、年龄、肿瘤直径以及突触素、嗜铬粒素A、神经元特异性烯醇化酶表达是否阳性患者术后3年累计生存率比较,差异均无统计学意义(均P>0.05)。28例患者术后3年累计生存率为50.0%,就诊时发生转移患者的预后明显差于未转移患者(P<0.05),混合性腺神经内分泌癌(MANEC)患者的预后明显差于单纯NEC患者(P<0.05),Ki-67增殖指数>55%的患者预后明显差于≤55%的患者(P<0.05)。结论就诊时发生转移、MANEC、Ki-67增殖指数增高的结直肠NEC患者预后较差。更多还原

【Abstract】 Objective To analyze the relationship of clinicopathological features of colorectal neuroendocrine carcinoma(NEC) with prognosis of patients. Methods Clinicopathological data of 28 patients with colorectal NEC admitted in Zhejiang Cancer Hospital between January 2012 and July 2020 were retrospectively reviewed, and the relationship of clinicopathological features with prognosis of patients was analyzed. Results The overall 3-year survival rate was 50.0% in this group of patients, it was significantly correlated with synchronous metastases, pathology grades and Ki-67 index(P<0.05), while not correlated with age, sex, tumor size, Syn, CGA and NSE(P >0.05). Univariate analysis showed that synchronous metastases,mixed adenoendocrine carcinoma, and Ki-67 index>55% indicated poor survival rate(P<0.05). Conclusion Synchronous metastases, pathology grade, and Ki-67 index are related to the prognosis of patients with colorectal NEC.更多还原