【摘要】 脓毒症肝损伤是脓毒症严重并发症之一,肝损伤的出现往往提示患者病情危重,预后不良。近年来,大量研究表明,细胞自噬在脓毒症肝损伤进展过程中起着极其重要的保护作用,通过改善微循环障碍、清除受损线粒体以及炎症因子来降低肝损伤严重程度。充分了解细胞自噬发生的机制以及在脓毒症肝损伤方面的作用,将对临床治疗脓毒症肝损伤的进展起到一定推进作用。现就细胞自噬在脓毒症肝损伤中的作用进行综述。更多还原

【Abstract】 Sepsis-induced liver injury is one of the serious complications of sepsis. The occurrence of liver injury often indicates that the patient’s condition is critical and the prognosis is poor.In recent years,a large number of studies have shown that autophagy plays an important role in the development of sepsis-induced liver injury. It can reduce the severity of liver injury by improving microcirculation,clearing damaged mitochondria and inflammatory factors. A thorough understanding of the mechanism of autophagy and its role in sepsis-induced liver injury may help to promote the clinical treatment of sepsis-induced liver injury. This article reviews the role of autophagy in sepsis liver injury.更多还原