【摘要】 目的探讨舍曲林长程干预对老年急性缺血性脑卒中患者预后的影响。方法前瞻性纳入江门市新会区人民医院神经内科自2018年1月至2020年7月收治的120例老年急性缺血性脑卒中患者为研究对象。按随机数字表法分为治疗组和对照组,每组60例。对照组接受脑卒中常规治疗,治疗组在常规治疗基础上加服盐酸舍曲林片治疗。对比2组患者不同时期(基线和起病1、3、6个月)神经功能、抑郁情绪、生活质量、生活能力的差异。结果 2组患者在起病1、3、6个月的美国国立卫生研究院卒中量表评分、汉密顿抑郁量表评分、生活质量综合评定量表评分、Barthel指数评分构成比对比,差异有统计学意义(P<0.05);治疗组患者神经功能和生活能力恢复较对照组好,抑郁水平比对照组低,生活质量较对照组高。结论舍曲林对老年急性脑卒中患者长程干预的疗效肯定,安全性好,能更明显促进神经功能的恢复,改善患者精神状态,提高患者远期生活质量,改善预后。更多还原

【Abstract】 Objective To investigate the effect of long-term sertraline intervention on the prognosis of elderly patients with acute ischemic stroke. Methods Prospectively enrolled 120 elderly patients with acute ischemic stroke admitted to Neurology Department of People ’s Hospital of Xinhui District from January 2018 to July 2020. According to the random number method, they were divided into observation group and control group, each with 60 cases. The control group received conventional treatment of stroke, the observation group was treated with sertraline hydrochloride tablets on the basis of conventional treatment. The two groups of patients were compared in different periods(baseline, onset 1,3, 6 months), neurological function, depression, Differences in quality of life and ability to live.Results There was a statistically significant difference in the composition ratio of the National Institute of Health Stroke scale score, Hamilton depression scale score, GQOLI-74 score, Barthel index score between the two groups of patients at 1, 3, and 6 months(P <0.05). The functional recovery was better than that of the control group, the depression level was lower than that of the control group, the quality of life was higher than that of the control group, and the recovery of living ability was better than that of the control group. Conclusion Sertraline has a positive effect on long-term intervention in elderly patients with acute stroke, and has good safety. It can significantly promote the recovery of neurological function,improve the mental state of patients, improve the long-term quality of life of patients, and improve the prognosis.更多还原