【摘要】 目的探讨使用肉毒杆菌毒素A型(BoNTA)治疗慢性偏头痛(CM)的疗效。方法回顾性分析西南医科大学附属成都三六三医院神经外科自2018年6月至2019年6月收治的47例CM患者的临床资料。所有患者均使用BoNTA治疗,采用术前和术后问卷调查比较疼痛的严重程度和每月疼痛发作次数。结果治疗前患者报告的平均疼痛发作次数中位数为12(9,16)次/月,治疗后减少到3(1,5)次/月。术前患者疼痛强度的中位数为7(7,8)分,治疗后降低至1(1,5)分。11例患者术后疼痛完全消除,28例患者症状明显缓解,3例患者症状有效缓解,仅5例患者术后没有任何明显的改善。平均随访时间为11.06个月。结论对于CM患者,BoNTA治疗可提供良好的治疗效果。更多还原

【Abstract】 Objective To study the therapeutic effect of botulinum toxin serotype A(BoNTA) in the treatment of chronic migraine(CM). Methods A retrospective analysis was performed on 47 patients with CM admitted to the Department of Neurosurgery, Chengdu 363 Hospital from June 2018 to June 2019. All patients were treated with BoNTA. The severity of pain and the number of pain episodes per month were compared by preoperative and postoperative questionnaires. Results The average pain incidence reported by the patients before operation was 12(9,16) times per month, but the average pain incidence reported by the patients after operation was reduced to 3(1,5) times per month. The mean pain score also decreased from 7(7,8) points before surgery to 1(1,5) points after injection. Eleven patients reported pain free after injection, 28 patients reported significant relief of pain, 3 patients reported effective relief of pain, and only 5 patients reported no significant postoperative improvement. The mean follow-up time was 11.06 months. Conclusion BoNTA is a feasible and promising treatment for CM.更多还原