【摘要】 目的:分析真实世界中化疗引起的恶心和呕吐(chemotherapy-induced nausea and vomiting,CINV)的个体化诊疗模式对胃肠道恶性肿瘤患者的CINV控制效果及对生存质量的影响。方法:选取2018年10月至2020年10月就诊于河北医科大学第四医院接受中度致吐风险化疗方案的289例胃肠道恶性肿瘤患者,按照CINV评估治疗方法分为CINV个体化诊疗组(A组)和医师选择诊疗组(B组),分析比较两组CINV控制效果及对生存质量的影响。结果:289例患者中A组146例,B组143例。A组全程恶心(74.66%vs. 34.27%,P<0.001)、呕吐(87.67%vs. 55.94%,P<0.001)完全控制率均明显优于B组,A组急性期及延迟期恶心、呕吐完全控制率优于B组。同时,A组患者在生存质量的功能领域(躯体功能、角色功能、社会功能),症状领域(恶心呕吐、疲倦、失眠、厌食),以及总体健康状况方面均表现出显著的优势。结论:个体化CINV诊疗模式可显著改善真实世界中胃肠道恶性肿瘤患者的CINV控制率和生存质量。更多还原

【Abstract】 Objective: To analyze the effect of individualized diagnosis and treatment of chemotherapy-induced nausea and vomiting(CINV) in the real world on the control rate of CINV and quality of life in patients with gastrointestinal cancer. Methods: From October2018 to October 2020, 289 patients with gastrointestinal cancer who were admitted to the Fourth Hospital of Hebei Medical University and received a chemotherapy regimen with moderate CINV risk were recruited. Patients were assigned into an individualized CINV treatment group(group A) and a doctor evaluation treatment group(group B). The control rate of CINV and its influence on quality of life were compared between the two groups. Results: There were 146 and 143 cases in groups A and B, respectively. The complete control rates of nausea(74.66% vs. 34.27%, P<0.001) and vomiting(87.67% vs. 55.94%, P<0.001) were significantly better in group A than in group B. The complete control rates of nausea and vomiting during the acute and delayed phases in group A were significantly better than those in group B. Meanwhile, patients in group A showed significant advantages in terms of quality of life, with respect to functional domains(physical function, role function, and social function), symptom domains(nausea and vomiting, fatigue, insomnia,and anorexia), and overall health status. Conclusions: Individualized CINV treatment can significantly improve the CINV control rate and quality of life in patients with gastrointestinal cancer.更多还原