【摘要】 目的探讨甲状腺癌患者选择甲状腺癌根治术+甲状旁腺自体移植术治疗的效果。方法选取2018年6月至2021年6月间上海市杨浦区控江医院接诊的86例甲状腺癌患者,根据随机数表法把患者均分为对照组和观察组,每组43例。对照组给予单纯的甲状腺癌根治术治疗,观察组给予甲状腺癌根治术+甲状旁腺自体移植术治疗。比较两组疗效,术后1d、1周和1个月的甲状旁腺激素(PTH)水平和甲状旁腺功能减退情况。结果观察组的总有效率(97.7%)显著高于对照组(86.0%),差异有统计学意义(P <0.05)。术后1d,两组的PTH水平均较低,差异无统计学意义(P> 0.05);术后1周和1个月,两组的PTH水平较术后1d均升高,差异均有统计学意义(P <0.05),且观察组术后1周和1个月的PTH水平均高于对照组,差异均有统计学意义(均P <0.05)。观察组短暂性、永久性甲状旁腺功能减退的发生率均低于对照组,差异均有统计学意义(均P <0.05)。结论甲状腺癌患者选择甲状腺癌根治术+甲状旁腺自体移植术治疗的效果显著,安全性强,可以防止患者发生永久性的甲状旁腺功能减退,利于疾病转归,值得临床上应用及推广。更多还原

【Abstract】 Objective To observe the efficacy of radical resection plus parathyroid autotransplantation for thyroid cancer. Methods A total of 86 patients with thyroid cancer admitted in Kongjiang Hospital were selected from June 2018 to June 2021. Using the random number table method,these patients were divided into an observation group and a control group,with 43 patients in each group. The observation group was treated with radical resection plus parathyroid autotransplantation and the control group underwent radical resection of thyroid cancer. The treatment efficacy was compared between the two groups. The levels of parathyroid hormone( PTH) and hypoparathyroidism were recorded at 1 d,1 week and 1 month after the surgery. Results The overall efficacy rate was 97. 7% in the observation group which was significantly higher than 86. 0% of the control group( P < 0. 05). At 1 d after the operation,PTH levels were low in the two groups,and the difference was not statistically significant( P > 0. 05). At 1 week and 1 month after the operation,PTH levels increased in the two groups compared with those at 1 d after the operation( all P <0. 05). Moreover,PTH levels were significantly higher in the observation group than in the control group at1 week and 1 month after the operation( all P < 0. 05). The incidence of transient and permanent hypoparathyroidism was significantly lower in the observation group than in the control group( all P < 0. 05).Conclusion Radical resection plus parathyroid autotransplantation was effective and safe for the treatment of thyroid cancer. It can prevent patients from developing permanent hypoparathyroidism,which ibenefits in prognosis and is worthy of clinical application and promotion.更多还原