【摘要】 目的探讨硝苯地平控释片联合小剂量阿司匹林肠溶片治疗妊娠期高血压的效果。方法选取2018年6月至2020年4月江西省赣州市妇幼保健院收治的80例妊娠期高血压患者作为研究对象,采用盲选法分为观察组(40例)与对照组(40例)。对照组采用单用硝苯地平控释片治疗,观察组在对照组的基础上加用小剂量阿司匹林肠溶片联合治疗。比较两组孕妇的治疗总有效率、不良反应总发生率、不良妊娠事件总发生率及心脏功能情况。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组的不良反应总发生率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的射血分数(EF)、每搏输出量(SV)、心输出量(CO)均高于对照组,舒张早/晚峰值流速(E/A)低于对照组,差异有统计学意义(P<0.05);观察组的不良妊娠事件总发生率低于对照组,差异有统计学意义(P<0.05)。结论妊娠期高血压患者应用硝苯地平控释片联合小剂量阿司匹林肠溶片治疗,在保证用药安全性的同时还能有效改善心功能及妊娠结局,疗效尚佳。更多还原

【Abstract】 Objective To investigate the effect of Nifedipine Controlled-release Tablets combined with low-dose Aspirin Enteric-coated Tablets in the treatment of hypertension during pregnancy. Methods A total of 80 patients with hypertension during pregnancy who were admitted to Ganzhou Maternal and Child Health Hospital of Jiangxi Province from June 2018 to April 2020 were selected as the research subjects, and they were divided into the observation group(40 patients) and the control group(40 patients) by the blind selection method. The control group was treated with Nifedipine Controlled-release Tablets alone, and the observation group was added low-dose Aspirin Enteric-coated Tablets on the basis of the control group. The total effective rates, the total incidences of adverse reactions, the total incidence of adverse pregnancy events and the cardiac function of pregnant women in the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). The total incidence of adverse reactions of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). The ejection fraction(EF), stroke volume(SV) and cardiac output(CO) in the observation group after treatment were higher than those in the control group,and the early/late diastolic peak flow rate(E/A) in the observation group after treatment was lower than that in the control group, and the differences were statistically significant(P<0.05). The total incidence of adverse pregnancy events of the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05).Conclusion Nifedipine Controlled-release Tablets combined with low-dose Aspirin Enteric-coated Tablets can effectively improve the cardiac function and pregnancy outcome in patients with hypertension during pregnancy with good efficacy. Simultaneously, it can also ensure the safety of medication.更多还原