【摘要】 目的观察急性白血病(AL)患者外周血T淋巴细胞亚群指标,并分析其在临床的应用价值。方法选取2018年2月至2020年2月上饶市人民医院收治的30例AL患者作为观察组,并根据受累细胞类型分为急性髓细胞性白血病(AML)组和急性淋巴细胞性白血病(ALL)组,每组各15例。分别于诱导缓解前后采用流式细胞术对其外周血T淋巴细胞亚群水平进行检测。同时选取30例健康体检者作为对照组,对其T淋巴细胞亚群指标进行数据对比,观察CD3~+、CD4~+、CD8~+在诱导缓解前后的数据值,并分析其在临床的应用价值。结果观察组的CD3~+、CD4~+低于对照组,CD8~+高于对照组,且AML组的CD3~+、CD4~+高于ALL组,CD8~+低于ALL组,差异有统计学意义(P<0.05);观察组治疗后的CD3~+、CD4~+高于治疗前,CD8~+低于治疗前,差异有统计学意义(P<0.05)。结论 AL外周血T淋巴细胞水平明显降低,但经相关治疗后基本恢复正常,说明T淋巴细胞亚群检测在评价疗效及判断预后等方面均具有一定的临床价值,可借助该检测手段去鉴别诊断血液肿瘤等血液病,对于预防疾病发作具有重要意义。更多还原

【Abstract】 Objective To observe the peripheral blood T lymphocyte subsets in patients with acute leukemia(AL), and analyze their clinical application value. Methods From February 2018 to February 2020, 30 patients with AL admitted to Shangrao People′ s Hospital were selected as the observation group, and they were divided into acute myeloid leukemia(AML) group and acute lymphoblastic leukemia(ALL) group according to the type of affected cells, with 15 cases in each group.The levels of peripheral blood T lymphocyte subsets were detected by flow cytometry before and after remission induction. Meanwhile, 30 healthy individuals admitted to Shangrao People′ s Hospital were selected as the control group. T lymphocyte subsets were comparatively analyzed. The changes in CD3~+, CD4~+and CD8~+before and after remission induction were observed, and their clinical application value was analyzed. Results CD3~+and CD4~+in the observation group were lower than those in the control group, while CD8~+ was higher than those in the control group.CD3~+and CD4~+in the AML group were higher than those in the ALL group, while CD8~+was lower than those in the ALL group, with statistical significances(P<0.05). After treatment, CD3~+and CD4~+were higher than before treatment,while CD8~+was lower than before treatment, the differences were statistically significant(P<0.05). Conclusion The levels of peripheral blood T lymphocytes decrease significantly in patients with AL, but they recovered after related treatments, indicating that T lymphocyte subsets detection is of certain clinical value in curative effect evaluation and prognosis. This detection method can be used to diagnose blood diseases like hematological malignancies, which is of great significance for preventing onset of the diseases.更多还原