【摘要】 目的探讨不同剂量瑞马唑仑用于全身麻醉诱导的临床效果。方法选取2021年1月至3月连云港市第一人民医院收治的100例择期行全身麻醉气管插管手术患者作为研究对象,按照随机数字表法分为A组（25例）、B组（25例）、C组（25例）和D组（25例）。四组全麻诱导均采用舒芬太尼和顺式阿曲库铵,在此基础上A组使用丙泊酚2 mg/kg,B组使用瑞马唑仑0.2 mg/kg、C组使用瑞马唑仑0.3 mg/kg、D组使用瑞马唑仑0.4 mg/kg。比较四组入手术室时（T₀）、给药后脑电双频指数（BIS）≤60时（T₁）、气管插管时（T₂）的平均动脉压（MAP）和心率（HR）;比较四组的给药起效时间和追加给药次数;比较四组的不良反应发生情况;术后第1天对患者进行术中知晓评估。结果 T₁时四组的MAP和HR低于同组T₀时间点,差异有统计学意义（P<0.05）,T₀、T₁和T₂时四组的MAP和HR组间比较,差异无统计学意义（P>0.05）。B、C和D组的药物起效时间长于A组,B组的起效时间长于C和D组,C组的起效时间长于D组,差异有统计学意义（P<0.05）。B组追加给药次数多于A、C和D组,差异有统计学意义（P<0.008）。B、C、D三组的不良反应总发生率低于A组,差异有统计学意义（P<0.008）。四组患者均未见术中知晓的发生。结论瑞马唑仑可有效、安全地应用于气管插管全身麻醉的麻醉诱导,且剂量为0.3 mg/kg效果及安全性较佳。更多还原

【Abstract】 Objective To investigate the clinical effect of different doses of Remazolam on induction of general anesthesia.Methods A total of 100 patients undergoing elective tracheal intubation under general anesthesia admitted to the First People′s Hospital of Lianyungang from January to March 2021 were selected as the research subjects,and they were divided into group A （25 cases）,group B （25 cases）,group C （25 cases） and group D （25 cases） according to random number table method.Sufentanil and Cisatracurium were used for induction of general anesthesia in all four groups.On this basis,group A was treated with 2 mg/kg Propofol,group B was treated with 0.2 mg/kg Remazolam,group C was treated with 0.3 mg/kg Remazolam,and group D was treated with 0.4 mg/kg Remazolam.The mean arterial pressure （MAP） and heart rate （HR） of the four groups were compared at entry into the operating room （T₀）,bispectral index of electroencephalogram after drug administration （BIS）≤60 （T₁） and endotracheal intubation （T₂）.The onset time and times of additional administration were compared among the four groups.The incidence of adverse reactions in four groups was compared.Intraoperative awareness assessment was performed 1 day after surgery.Results At T₁,MAP and HR of the four groups were lower than those of the same group at T₀,the difference was statistically significant （P<0.05）,but there was no significant difference between MAP and HR of the four groups at T₀,T₁and T₂（P>0.05）.The onset time of drugs in groups B,C and D was longer than that in group A,group B was longer than that in groups C and D,and group C was longer than that in group D,with statistical significance （P<0.05）.The frequency of additional administration in group B was higher than that in groups A,C and D,and the difference was statistically significant （P<0.008）.The total incidence of adverse reaction in group B,C and D was lower than that in group A,and the differences were statistically significant （P<0.008）.None of the patients in the four groups had any known intraoperative occurrence.Conclusion Remazolam can be used effectively and safely in induction of general anesthesia with tracheal intubation,and the effect and safety of 0.3 mg/kg is better.更多还原