【摘要】 DKD是DM重要的微血管并发症之一,也是终末期肾病的主要原因。TGF-β是一种存在于慢性肾脏病中的促纤维化生长因子,可调节多种病理过程,其通过Smad信号通路诱导肾细胞产生细胞外基质,促进肾脏纤维化,导致肾小球硬化和肾小管间质纤维化。靶向TGF-β抗纤维化对DKD有益。本文从抑制这些信号通路及其相关因子出发,为防治DKD提供新途径。更多还原

【Abstract】 Diabetic kidney disease(DKD)is one of the important microvascular complications of diabetes mellitus and the main cause of end-stage renal disease. Transforming growth factor-β（TGF-β）is a pro-fibrotic growth factor existing in chronic renal disease,which can regulate a variety of pathological processes. TGF-βcan induce renal cells through the Smad signaling pathway,produce extracellular matrix,promote renal fibrosis,and lead to glomerular sclerosis and renal tubulointerstitial fibrosis. Various studies have shown the beneficial effect of targeting TGF-β against fibrosis in DKD. Therefore,inhibition of these signaling pathways and their related factors may provide a new way for the prevention and treatment of DKD.更多还原