【摘要】 以聚甲基丙烯酸甲酯(PMMA)为原料,通过注塑加工的方式制备微流控芯片,经过多次注塑实验得出影响PMMA微流控芯片成型质量的主要因素是:模具温度、保压压力、熔体温度和注射速度。在其他参数不变的情况下,通过正交实验和极差分析确定了PMMA微流控芯片注射成型的最佳工艺:熔体温度260℃,模具温度50℃,保压压力60 MPa,注射速度400 mm/s,在该工艺条件下制得的单流道测试装置B的开口宽度、槽底宽度、槽深分别为:591.90、381.26、408.47μm,这些参数所对应的设计值分别为:400、400、400μm;在共聚焦显微镜下观察到芯片表面较为洁净、微结构比较完整,最后使用该微流控芯片完成了液体混合实验和液滴生成实验,表明最佳注塑工艺加工出的微流控芯片能满足正常使用,对于未来微流控芯片的批量化生产有着重要意义。更多还原

【Abstract】 The microfluidic chip was manufactured by injection molding with poly(methyl methacrylate)(PMMA)as a raw material. Through a series of injectionmolding experiments,it was found that the mold temperature,holding pressure,melt temperature and injection speed were considered as the main factors affecting the molding quality of the PMMA microfluidic chip. Through the orthogonal experiment and range analysis,the optimal injectionmolding process parameters for the PMMA microfluidic chip was determined to be a melt temperature of 260 ℃,a mold temperature of 50 ℃,a holding pressure of 60 MPa and an injection speed of 400 mm/s without changing other parameters. The singlechannel test device B achieved a top width of 591. 90 μm,a bottom width of 381. 26 μm and a depth of 408. 47 μm under this processing condition with the design value of 400 μm for these three parameters. The confocal microscope observation indicated that the chip surface was relatively clean and its microstructure was relatively complete. In addition,the liquidmixing and dropletgenerating experimental results indicated the microfluidic chip manufactured by the optimal injectionmolding process parameters could meet the normal requirement for use. This is of great significance for the mass production of the microfluidic chip in future.更多还原