【摘要】 目的探讨术前MRI显示的瘤周水肿特征与幕上高级别胶质瘤病人预后的相关性。方法回顾性分析2017年1月至2019年3月手术治疗的、经术后病理证实的105例幕上高级别胶质瘤的临床资料。根据术前MRI评估瘤周水肿程度。随访截止时间为2020年6月。105例术后随访6～36个月,平均17个月。生存期是指从初次手术到死亡或末次随访的时间。结果 105例中,轻度瘤周水肿42例,重度63例。105例病人中位生存期为15个月。多因素Cox回归分析结果显示,术前MRI显示重度瘤周水肿是高级别胶质瘤生存预后不良的独立危险因素(P<0.05)。生存曲线分析结果显示,重度瘤周水肿病人中位生存时间(14.0个月)较轻度瘤周水肿病人(30.0个月)明显缩短(P<0.001)。结论术前常规MRI显示的严重瘤周水肿与幕上高级别胶质瘤病人生存预后密切相关,瘤周水肿越严重,病人预后越差。更多还原

【Abstract】 Objective To explore the correlation between the peritumoral edema before surgery and the prognoses of patients with supratentorial high-grade glioma. Methods The clinical data of 105 patients with supratentorial high-grade glioma who underwent surgery from January 2017 to March 2019 were retrospectively analyzed. The imaging characteristics of peritumoral edema were evaluated by preoperative MRI. The follow-up deadline was June 2020. The followed up ranged fro 6 months to 36 months, with an average of 17 months. Survival time was difined as the time from initial surgery to death or last follow-up. Results Of 105 patients, mild peritumoral edema occurred in 42 patients, severe in 63. The median survival time of 105 patients was 15 months. Multivariate Cox regression analysis showed that severe peritumoral edema was an independent risk factor for poor survival prognosis of high grade glioma patients(P<0.05). Survival curve analysis showed that the median survival time(14.0 months) of patients with severe peritumoral edema was significantly shorter than that(30.0 months) of patients with mild peritumoral edema(P<0.001). Conclusions Peritumoral edema is closely related to the survival prognosis of patients with supratentorial high grade glioma. The more severe the peritumoral edema, the worse the prognosis of the patient with supratentorial high grade glioma.更多还原