【摘要】 目的探讨急性青年脑梗死(young acute cerebral Infarction,YACI)血小板及淋巴细胞比值(platelet tolymphocyte ratio,PLR)与出血转化(hemorrhagic transformation,HT)的相关性。方法按照发生HT与否,将首次入院的152例YACI患者分为HT组(36例)及非出血转化组(non-hemorrhagic transformation group n HT,116例),根据出血体积将HT组分为大出血组(8例)、中出血组(11例)和小出血组(17例),根据NIHSS评分评估患者神经功能缺损的程度,分析PLR与YACI患者发生HT及NIHSS评分的关系。结果观察组PLR数值显著高于对照组,PLR数值在NIHSS评分轻度组、中度组、重度组中均有统计学差异,PLR数值在HT组高于非HT组,在SH组、MH组及LH组间均有统计学差异(均P <0.05);观察组PLR数值与NIHSS评分呈正相关(r=0.638,P=0.036),HT组患者PLR数值与出血体积呈正相关(r=0.714,P=0.029)。结论 YACI患者PLR数值升高与YACI后出血体积及NIHSS评分均呈正相关,在一定程度上可以预测YACI患者发生HT的可能性。更多还原

【Abstract】 Objective To measure the platelet to lymphocyte ratio( PLR) of young acute cerebral infarction( young acute cerebral infarction,YACI) patients,and to analyze its possible correlation with hemorrhagic transformation( HT) in YACI patients. Methods According to the occurrence of HT,152 YACI patients admitted were divided into HT group( 36 cases) and non hemorrhagic transformation group( 116 cases). According to the bleeding volume,HT group was divided into large bleeding group( 8 cases),medium bleeding group( 11 cases) and small bleeding group( 17 cases). The degree of neurological deficit was evaluated according to NIHSS score. The relationship between PLR and HT and NIHSS score in YACI patients was analyzed. Results The PLR value in the observation group was significantly higher than that in the control group,there were significant differences in the NIHSS score of mild group,moderate group and severe group,the PLR value in HT group was higher than that in non HT group,there were significant differences among SH group,MH group and LH group( all P < 0. 05). The PLR value in the observation group was positively correlated with NIHSS score( r = 0. 638,P =0. 036),and the PLR value in HT group was positively correlated with bleeding volume( r = 0. 714,P = 0. 029).Conclusion The increase of PLR in YACI patients was positively correlated with post YACI bleeding volume and NIHSS score,which could predict the possibility of HT in YACI patients to a certain extent.更多还原