【摘要】 目的研讨抑郁障碍全病程规范化治疗和康复关键技术的研究与应用效果研究。方法选取2015年1月至2016年12月期间我院收治的208例抑郁障碍患者作为研究受试对象,根据随机数字法分组,对照组104例接受心理及认知康复治疗,观察组104例患者则在对照组基础上联合全病程规范化治疗,评价比较两组患者的抑郁状态缓解情况(EPDS)及相关神经免疫学指标。结果与干预前比较,干预后两组患者4周末及8周末的EPDS评分均明显降低,且观察组评分降低幅度更大,差异有统计学意义(P<0.05);与干预前比较,两组患者的血清5-HT、IL-4、IL-10等指标水平均呈现上升趋势,且观察组的上升幅度明显高于对照组,差异有统计学意义(P<0.05);两组的IL-1β、IL-6水平较干预前均降低,观察组的IL-1β水平明显低于对照组(P<0.05),干预后两组的IL-6水平比较,差异无统计学意义(P>0.05)。结论全病程规范化治疗联合康复关键技术干预可有效改善患者的抑郁状态,调整血清5-HT、Th1及Th2所分泌炎性细胞因子导致的失衡状态,对促进患者康复有积极作用。更多还原

【Abstract】 Objective To investigate standardized treatment for the whole course on depressive disorder and key technologies for rehabilitation and the efficacy of their application. Methods From January 2015 to December 2016, 208 patients with depressive disorder admitted to our hospital were selected as the research objects. According to the random number table method, patients in the control group(n=104) were given psychological and cognitive rehabilitation treatment, while patients in the observation group(n=104) were given standardized treatment for the whole course on the basis of the control group. The Edinburgh postnatal depression scale(EPDS) and related neuroimmunology indexes of the two groups were evaluated and compared. Results Compared with the baseline level before intervention, the EPDS scores of patients in the two groups decreased significantly at the 4 th and 8 th weekends after the intervention, and the scores in the observation group decreased even more, with statistically significant differences(P<0.05). Compared with the baseline level before intervention, the levels of serum 5-HT, IL-4, IL-10 and other indexes in the two groups were shown an increasing tendency, and the increase rate in the observation group was significantly higher than that in the control group, with statistically significant differences(P<0.05). The levels of IL-1β and IL-6 in the two groups were lower than those before intervention, and the level of IL-1β in the observation group was significantly lower than that in the control group(P<0.05). There was no significant difference in IL-6 level between the two groups after intervention(P>0.05). Conclusion Standardized treatment for the whole course combined with key technologies for rehabilitation intervention effectively improve the depression state of patients, adjust the imbalance state caused by inflammatory cytokines secreted by serum 5-HT, Th1 and Th2, and play a positive role in promoting the rehabilitation of patients.更多还原