【摘要】 为探究药物的黏度对微射流注射特性和注射效果的影响,配制不同浓度的甘油水溶液进行注射。利用高速摄影技术观察不同黏度液体射流的传播过程和雾化程度;通过压力传感器对射流的冲击压力进行动态测量;借助均质凝胶探究液体黏度对射流在凝胶中的扩散形状的具体影响。研究结果表明:液体黏度越大,射流扩散角越小,射流雾化程度越低;液体黏度对注射持续时间、波动段时间的影响较小,但稳定段压力随黏度增大呈上升趋势。黏度为18 mPa·s的液体在凝胶试验中的扩散形状深宽比小于其他黏性液体。因此,黏度为18 mPa·s的液体有利于药液的横向扩散,能带来更好的注射体验。更多还原

【Abstract】 To explore the influence of drug viscosity on injection performances and the dispersion pattern of microjet, glycerol-water solutions of different concentrations were used for injection experiments. The high-speed photography technique was employed to observe the propagation progress and atomization of the jets. The impact pressures of the jets were measured with a dynamic sensor. Then, the dispersion patterns of different viscous liquid jets’ penetration into homogeneous gelatin were investigated. The results demonstrate that with the increase of viscosity, the spray angle and atomization degree decrease. The liquid viscosity has little effect on the duration of injection and the time of fluctuation, whereas the steady pressure increases with the increase of viscosity. In gelatin injections experience, the aspect ratio of the diffusion shape of the liquid with viscosity of 18 mPa·s is smaller than that of other viscous liquids. Therefore, the jet injection with a liquid viscosity of 18 mPa·s is likely to spread better in the lateral direction compared with those of other viscosity, bringing a satisfactory injection experience.更多还原