【摘要】 目的探讨理想心血管健康指标对颈动脉内中膜异常增厚的影响。方法研究选取2020年3月至2021年2月在江门市中心医院体检中心参加健康体检的人群共1 000名为研究对象,收集受试者身高、体质量、吸烟史等一般临床资料及基线血压、血糖、血脂水平,同时计算受试者理想心血管健康指标符合数目。所有受试者完善颈部血管超声,记录受试者颈动脉内中膜厚度(CIMT),将患者分为颈动脉内中膜异常增厚组和正常组,通过Logistic回归分析两组之间一般临床资料及理想心血管健康指标对颈动脉内中膜增厚的影响。结果统计结果显示,CIMT增厚组年龄偏大,女性比例偏少,吸烟比例偏高,理想血压和理想血糖患者比例低于CIMT正常组,差异有统计学意义(P <0.05)。其他指标两组患者间无显著性差异(P> 0.05)。多因素分析发现,ICVH指标数> 4是CIMT异常增厚的保护性因素[比值比(OR)为0.72,95%可信区间(95%CI)为0.60～0.88,P=0.021],在校正了性别、年龄后,该统计学差异仍然存在(OR=0.82,95%CI 0.64～0.91,P=0.027)。结论颈动脉内中膜异常增厚者理想心血管健康因素的指标数低于无颈动脉内膜增厚者,改善心血管健康指标可以降低中老年人群颈动脉内中膜异常增厚的风险。更多还原

【Abstract】 Objective To investigate the effect of ideal cardiovascular health indicators on abnormal thickening of carotid intima-media. Methods The study selected 1 000 subjects from March 2020 to February 2021 who participated in the health examination at the Jiangmen Central Hospital Physical Examination Center, and collected general clinical data such as height, weight, smoking history, and baseline blood pressure, blood glucose and blood lipid levels, and calculate the number of subjects’ ideal cardiovascular health indicators. All subjects perfected cervical vascular ultrasound and recorded the carotid artery intima-media thickness(CIMT). The patients were divided into abnormal carotid artery intima-media thickening group and normal group. Logistic regression was used to analyze the general difference between the two groups. The effect of clinical data and ideal cardiovascular health indicators on carotid artery intima-media thickening. Results The statistical results showed that the age of patients in CIMT thickening group was older, the proportion of women was less, the proportion of smoking was higher, the proportion of patients with ideal blood pressure and ideal blood glucose was lower than that in CIMT normal group, the difference was statistically significant(P<0.05). There was no significant difference in other indexes between the two groups(P >0.05). Multivariate analysis showed that ICVH index number > 4 was a protective factor for abnormal thickening of CIMT [odds ratio(OR) was 0.72, 95% confidence interval(95% CI) was 0.60-0.88, P=0.021]. After adjusting for gender and age, the statistical difference still existed(OR=0.82, 95% CI 0.64-0.91, P =0.027). Conclusion The number of ideal cardiovascular health factors for patients with abnormal carotid intima-media thickening is lower than those without carotid artery intimal thickening. Improving cardiovascular health indicators can reduce the risk of abnormal carotid intima-media thickening in the middle-aged and elderly population.更多还原