【摘要】 药物成瘾是一种慢性复发的大脑疾病,会给个人和社会造成巨大的损失。因此,寻找有效的干预措施一直备受关注。记忆提取消退范式,利用再巩固时间窗进行消退训练修改成瘾记忆,是一种无须药物治疗和侵入性技术的心理行为治疗方法。相较于药物治疗和传统消退程序,这一方法更为安全高效。睡眠是能够进行记忆巩固的关键时期,有着提升记忆力的效果,因此,融合睡眠与记忆提取消退范式有良好的临床应用前景。本文将对记忆提取消退范式在药物成瘾中的研究进行综述,并从结合睡眠的角度进行展望,以期为药物成瘾的治疗提供新思路。更多还原

【Abstract】 Drug addiction is a chronic, relapsing brain disorder that causes huge losses on both individual and society levels. Therefore, the search for effective interventions has always been a concern. Retrieval-extinction is a psychobehavioral therapy that does not include pharmacotherapy and invasive treatment. It leverages extinction training to update addiction memory during the memory reconsolidation time window. This method is safer and more effective than pharmacotherapy and traditional extinction treatment. Sleep is a critical period for memory consolidation and has the effect of improving memory. Therefore, the fusion of sleep and memory lifting and cancellation paradigm has good clinical application prospects. This paper provides an in-depth review of retrieval-extinction in drug addiction treatment and explores the application of the multimodal treatment that involves both retrieval-extinction and sleep in the hope of developing novel treatments for drug addiction therapy.更多还原