【摘要】 通过对中医学"少阳"理论进行系统梳理,发现"少阳"理论与大肠癌转移关系密切。生理上,少阳为枢,沟通人体表里内外,维系气机升降出入,调畅津血情志。若少阳不利,则会导致人体内外沟通不畅,痰浊瘀血内生,气机升降乖戾,情志不畅精神失守。"少阳"理论可在以下几个方面影响大肠癌转移:一、少阳气化不利则痰浊瘀血等癌毒内生,二、少阳气机运转失常则癌毒转移,三、少阳枢机不利,机体内外不通则癌毒内郁,情志失常神机外泄则正虚无以抗癌。进一步将"少阳"理论同和现代研究进展联系可以发现,自噬异常、肠道菌群紊乱、肿瘤血管新生、免疫失常或是少阳不利导致肠癌转移的生物学基础。临证时注意从少阳出发,有利于防治大肠癌转移。更多还原

【Abstract】 By systematically combing the theory of “Shaoyang” in traditional Chinese medicine, it is found that the theory of “Shaoyang” is closely related to the metastasis of colorectal cancer. Physiologically, shaoyang is the pivot of the body, communicating the inside and outside of the body, maintaining the movement of qi, regulating the flow of fluid,blood and emotions. If shaoyang is unfavorable, it will lead to poor communication inside and outside the human body,form the turbid phlegm and blood stasis, disturb qi’s rise and fall, cause emotional disorder and spiritual failure.“Shaoyang” theory can affect the metastasis of colorectal cancer in the following aspects: first, the cancer toxin such as turbid phlegm and blood stasis will be endogenous if Shaoyang qi is not favorable; second, the cancer toxin will be transferred if qi mechanism is not working properly; third, if the Shaoyang cardinal mechanism is unfavorable, the body will be blocked inside and outside, the cancer toxin has no place to be released, emotional disorder and the supernatural power will leak out, then healthy qi deficiency can’t prevent cancer. Further connecting the theory of “Shaoyang”with the modern research progress, it can be found that abnormal autophagy,intestinal flora disorder, tumor angiogenesis and immune disorder may be the biological basis of intestinal cancer metastasis caused by unfavorable Shaoyang. It is helpful to prevent and treat the metastasis of colorectal cancer in consideration of “Shaoyang”.更多还原