【摘要】 本文从荧光素钠的原理、应用历史、对肿瘤切除程度的影响、不良反应、给药时间及方法、与5-氨基乙酰丙酸的比较等方面对荧光素钠引导的高级别胶质瘤显微切除术的临床研究进展进行回顾和分析。颅内高级别胶质瘤具有一定的弥漫浸润性生长的特性,荧光引导技术通过静脉注射荧光药物进行术中实时荧光标识肿瘤,可以实现术中肿瘤边界可视化,增强肿瘤边界的辨认度,提高肿瘤的切除程度;其价格低廉,易于储存,给药剂量易控制,安全性良好,因术中应用荧光素钠过敏导致的不良反应发生率较低。本文对荧光素钠在高级别脑胶质瘤显微切除术中的临床应用提供参考。更多还原

【Abstract】 This article reviews and analyzes the clinical research progress of sodium fluorescein guided high-grade glioma microsurgery in terms of its principle, application history, influence on tumor resection degree, adverse reactions, administration time and method, and comparison with five-aminolevulinic acid. Intracranial high-grade glioma has the characteristics of diffuse invasive growth. Fluorescence guided technology can realize the visualization of tumor boundary, enhance the recognition of tumor boundary, and improve the degree of tumor resection by intravenous injection of fluorescent drugs for real time intraoperative fluorescent labeling of tumor. It is cheap, easy to store, easy to control the dosage, good safety, and low incidence of adverse reactions caused by intraoperative application of fluorescein sodium. This article provides a reference for the clinical application of fluorescein sodium in the microsurgery of highgrade glioma.更多还原